Abstract:
We report here the synthesis as well as antioxidant activity of a series of 2-aryl thiazolidine-4-carboxylic
acids, including two novel derivatives. They were synthesized by nucleophilic cyclic condensation of L-cysteine
hydrochloride with a range of aromatic aldehydes. Their in vitro antioxidant activity was evaluated by DPPH radical
scavenging assay. It was observed that the aromatic substituent at C-2 of thiazolidine ring effects the antioxidant
potential of the thiazolidine derivatives. The nature and position of the substituents on aromatic ring were correlated with
antioxidant activity. Compounds with -OCH3 group on aromatic ring showed a better radical scavenging property than
the other groups such as -Cl, -F, and -NO2. The presence of phenyl ring thus enhanced radical scavenging activity.
