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Synthesis of (4R)-thiazolidine carboxylic acid and evaluation of antioxidant potential

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dc.contributor.author Begum, Nasreen
dc.contributor.author Anis, Itrat
dc.contributor.author Saeed, Syed Muhammad Ghufran
dc.contributor.author Ashraf, Seema
dc.contributor.author Choudhary, M. Iqbal
dc.date.accessioned 2022-10-27T10:30:19Z
dc.date.available 2022-10-27T10:30:19Z
dc.date.issued 2020-03-16
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13777
dc.description.abstract We report here the synthesis as well as antioxidant activity of a series of 2-aryl thiazolidine-4-carboxylic acids, including two novel derivatives. They were synthesized by nucleophilic cyclic condensation of L-cysteine hydrochloride with a range of aromatic aldehydes. Their in vitro antioxidant activity was evaluated by DPPH radical scavenging assay. It was observed that the aromatic substituent at C-2 of thiazolidine ring effects the antioxidant potential of the thiazolidine derivatives. The nature and position of the substituents on aromatic ring were correlated with antioxidant activity. Compounds with -OCH3 group on aromatic ring showed a better radical scavenging property than the other groups such as -Cl, -F, and -NO2. The presence of phenyl ring thus enhanced radical scavenging activity. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi en_US
dc.subject Antioxidant activity en_US
dc.subject DPPH en_US
dc.subject L-cysteine en_US
dc.subject free radical scavenging en_US
dc.subject (4R) Thiazolidine carboxylic acid en_US
dc.title Synthesis of (4R)-thiazolidine carboxylic acid and evaluation of antioxidant potential en_US
dc.type Article en_US


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