dc.contributor.author |
Begum, Nasreen |
|
dc.contributor.author |
Anis, Itrat |
|
dc.contributor.author |
Saeed, Syed Muhammad Ghufran |
|
dc.contributor.author |
Ashraf, Seema |
|
dc.contributor.author |
Choudhary, M. Iqbal |
|
dc.date.accessioned |
2022-10-27T10:30:19Z |
|
dc.date.available |
2022-10-27T10:30:19Z |
|
dc.date.issued |
2020-03-16 |
|
dc.identifier.issn |
1011-601X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/13777 |
|
dc.description.abstract |
We report here the synthesis as well as antioxidant activity of a series of 2-aryl thiazolidine-4-carboxylic
acids, including two novel derivatives. They were synthesized by nucleophilic cyclic condensation of L-cysteine
hydrochloride with a range of aromatic aldehydes. Their in vitro antioxidant activity was evaluated by DPPH radical
scavenging assay. It was observed that the aromatic substituent at C-2 of thiazolidine ring effects the antioxidant
potential of the thiazolidine derivatives. The nature and position of the substituents on aromatic ring were correlated with
antioxidant activity. Compounds with -OCH3 group on aromatic ring showed a better radical scavenging property than
the other groups such as -Cl, -F, and -NO2. The presence of phenyl ring thus enhanced radical scavenging activity. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi |
en_US |
dc.subject |
Antioxidant activity |
en_US |
dc.subject |
DPPH |
en_US |
dc.subject |
L-cysteine |
en_US |
dc.subject |
free radical scavenging |
en_US |
dc.subject |
(4R) Thiazolidine carboxylic acid |
en_US |
dc.title |
Synthesis of (4R)-thiazolidine carboxylic acid and evaluation of antioxidant potential |
en_US |
dc.type |
Article |
en_US |