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Design, synthesis and biological Evaluation of Dual acetyl cholinesterase and beta-secretase inhibitors in treatment for alzheimer’s Disease

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dc.contributor.author Deng, Youchao
dc.contributor.author Jiang, Yuren
dc.contributor.author Zhao, Xiongjie
dc.contributor.author Wang, Jinlian
dc.date.accessioned 2022-10-27T10:36:39Z
dc.date.available 2022-10-27T10:36:39Z
dc.date.issued 2019-09-15
dc.identifier.citation Deng, Y., Jiang, Y., Zhao, X., & Wang, J. (2019). Design, synthesis and biological Evaluation of Dual acetyl cholinesterase and beta-secretase inhibitors in treatment for alzheimer's Disease. Pakistan Journal of Pharmaceutical Sciences, 32(5). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13791
dc.description.abstract With the recent research advances in molecular biology and technology multiple credible hypotheses about the progress of Alzheimer’s disease (AD) have been proposed, among which the amyloid and cholinergic hypotheses are commonly used to develop reliable therapeutic agents. The multitarget-directed ligand (MTDL) approach was taken in this work to develop muilti-functional agents, which can mainly serve as dual beta-secretase (BACE 1) and Acetylcholinesterase (AChE) inhibitors. Series of new compounds were designed, synthesized and evaluated in this work, from which we identified 2-((4-(1,3-dioxoisoindolin-2-yl)benzyl)amino)-2-oxoethyl-2-(4-methoxyphenyl)acetate (1h) as a new dual cholinesterase and beta-secretase inhibitor without toxicity. en_US
dc.language.iso en_US en_US
dc.subject Beta-Secretase en_US
dc.subject Acetylcholinesterase en_US
dc.subject Inhibitor en_US
dc.subject Alzheimer’s Disease. en_US
dc.title Design, synthesis and biological Evaluation of Dual acetyl cholinesterase and beta-secretase inhibitors in treatment for alzheimer’s Disease en_US
dc.type Article en_US


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