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Phytochemical analysis and antimicrobial activity of aqueous and methanolic extracts of the flowers of Nelumbium speciosum

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dc.contributor.author Bashir, Sajid
dc.contributor.author Sial, Rubina Naureen
dc.contributor.author Ashraf, Muhammad Umer
dc.contributor.author Mushtaq, Muhammad Naveed
dc.contributor.author Adnan, Muhammad Abdul Jabar
dc.contributor.author Erum, Alia
dc.date.accessioned 2022-10-27T10:37:39Z
dc.date.available 2022-10-27T10:37:39Z
dc.date.issued 2018-11
dc.identifier.citation Bashir, S., Sial, R. N., Ashraf, M. U., Mushtaq, M. N., Adnan, M. A. J., & Erum, A. (2018). Phytochemical analysis and antimicrobial activity of aqueous and methanolic extracts of the flowers of Nelumbium speciosum. Pakistan Journal of Pharmaceutical Sciences, 31(6). en_US
dc.identifier.issn 1996-7195
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13792
dc.description.abstract In present investigation aqueous and methanolic extracts of Nelumbium speciosum flowers were screened for phytochemical constituents and antibacterial activity to ascertain their traditional use. Antimicrobial activity of both extracts was tested by Kirby-Bauer disc diffusion method against four Gram positive strains, viz. Staphylococcus aureus (ATCC25923), Streptococcus agalactiae (13813), Bacillus subtilis (ATCC 6633), Staphylococcus epidermidis (ATCC 12228) and four Gram negative bacterial strains Escherichia coli (ATCC 8739), Pseudomonas aeruginosa (ATCC 27853), Proteus mirabilis (12453) and Klebsiella pneumoniae (10031). Phytochemical analysis showed the presence of tannins, saponins and alkaloids in both extracts while flavonoids and steroids were present only in methanolic extract. Methanolic extract of Nelumbium speciosum flower showed concentration dependent antibacterial activity against all tested strains with maximum zone of inhibition (17.3±0.3mm) against P. aeruginosa. Aqueous extract showed concentration dependent activity against S. aureus, E. coli, B. subtilis and S. epidermidis with maximum antibacterial activity against E. coli (14.3±0.3mm). MIC of methanolic and aqueous extracts was in the range of 0.015-0.251 and 0.0625-0.251 mg/mL, respectively. Results showed that methanolic extract of Nelumbium speciosum exhibits superior antibacterial activity than aqueous extract. en_US
dc.language.iso en_US en_US
dc.publisher Pakistan Journal of Pharmaceutical Sciences University of Karachi en_US
dc.subject Antibacterial activity en_US
dc.subject Nelumbium speciosum en_US
dc.subject phytochemical analysis en_US
dc.title Phytochemical analysis and antimicrobial activity of aqueous and methanolic extracts of the flowers of Nelumbium speciosum en_US
dc.type Article en_US


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