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Synthesis of 2-Furyl[(4-aralkyl)-1-piperazinyl]methanone derivatives as suitable antibacterial agents with mild cytotoxicity

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dc.contributor.author Abbasi, Muhammad Athar
dc.contributor.author Nazeer, Muhammad Mubashar
dc.contributor.author Rehman, Aziz-ur-
dc.contributor.author Siddiqui, Sabahat Zahra
dc.contributor.author Hussain, Ghulam
dc.contributor.author Shah, Syed Adnan Ali
dc.contributor.author Ahmad, Irshad
dc.contributor.author Shahid, Muhammad
dc.contributor.author Sarwar, Muhammad Salman
dc.date.accessioned 2022-10-27T10:41:08Z
dc.date.available 2022-10-27T10:41:08Z
dc.date.issued 2018-11
dc.identifier.citation Abbasi, M. A., Nazeer, M. M., Siddiqui, S. Z., Hussain, G., Shah, S. A. A., Ahmad, I., ... & Sarwar, M. S. (2018). Synthesis of 2-Furyl [(4-aralkyl)-1-piperazinyl] methanone derivatives as suitable antibacterial agents with mild cytotoxicity. Pakistan journal of pharmaceutical sciences, 31(6). en_US
dc.identifier.issn 1996-7195
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13795
dc.description.abstract The aim of the present research work was synthesis of some 2-furyl[(4-aralkyl)-1-piperazinyl]methanone derivatives and to ascertain their antibacterial potential. The cytotoxicity of these molecules was also checked to find out their utility as possible therapeutic agents. The synthesis was initiated by reacting furyl(-1-piperazinyl)methanone (1) in N,N-dimethylformamide (DMF) and lithium hydride with different aralkyl halides (2a-j) to afford 2-furyl[(4-aralkyl)-1- piperazinyl]methanone derivatives (3a–j). The structural confirmation of all the synthesized compounds was done by IR, EI-MS, 1 H-NMR and 13C-NMR spectral techniques and through elemental analysis. The results of in vitro antibacterial activity of all the synthesized compounds were screened against Gram-negative (S. typhi, E. coli, P. aeruginosa) and Gram-positive (B. subtilis, S. aureus) bacteria and were found to be decent inhibitors. Amongst the synthesized molecules, 3e showed lowest minimum inhibitory concentration MIC = 7.52±0.µg/mL against S. Typhi, credibly due to the presence of 2-bromobenzyl group, relative to the reference standard, ciprofloxacin, having MIC = 7.45±0.58µg/mL. en_US
dc.language.iso en_US en_US
dc.publisher Pakistan Journal of Pharmaceutical Sciences University of Karachi en_US
dc.subject Furyl(-1-piperazinyl)methanone en_US
dc.subject aralkyl halides en_US
dc.subject antibacterial activity en_US
dc.subject cytotoxicity studies en_US
dc.title Synthesis of 2-Furyl[(4-aralkyl)-1-piperazinyl]methanone derivatives as suitable antibacterial agents with mild cytotoxicity en_US
dc.type Article en_US


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