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Comparative antioxidant and analgesic effect of sesame oil, fish oil and their combination in experimental animal model

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dc.contributor.author Naeem, Sadaf
dc.contributor.author Ali, Liaquat
dc.contributor.author Ikram, Rahila
dc.contributor.author Saeed Khan, Saira
dc.contributor.author Shareef, Huma
dc.contributor.author Shafiq, Yousra
dc.contributor.author Alam, Nausheen
dc.contributor.author Adil, Anum
dc.date.accessioned 2022-10-27T10:42:48Z
dc.date.available 2022-10-27T10:42:48Z
dc.date.issued 2021-03-02
dc.identifier.citation Naeem, S., Ali, L., Ikram, R., Khan, S. S., Shareef, H., Shafiq, Y., ... & Adil, A. (2021). Comparative antioxidant and analgesic effect of sesame oil, fish oil and their combination in experimental animal model. Pakistan Journal of Pharmaceutical Sciences, 34(2). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13797
dc.description.abstract Natural oils are rich in polyunsaturated fatty acids (PUFs) like omega 3, omega 6 and other nutrients that boost physical and mental health. Traditionally these oils have been used to treat joint pain associated with several inflammatory conditions. In this study, we investigated the antioxidant and analgesic properties of the sesame oil (SO), fish oil (FO) and combination of these two oils (SO+FO). Different concentrations of the SO, FO and SO+FO combination 0.02-4mg/ml were used for assessing the free radical scavenging activity by DPPH method and the IC50 value was calculated. Acetic acid-induced abdominal writhing test, tail immersion and hot plate models were used to determined analgesic effect. Results showed that both oils were well tolerated as no signs of toxicity or death were noticed during the observational study period. SO+FO combination showed the best antioxidant properties as shown by DPPH assay. Similarly in analgesic models, SO and FO significantly reduced the number of abdominal contractions (p<0.05) however, SO+FO (1:1) exhibited highly significant results (p<0.001) in writhing reflex test. Furthermore, SO and FO both increased the reaction time on a hot plate as well as in tail flick test (p<0.05) whereas, SO+FO significantly increased reaction time (p<0.001) in hot plate and in tail flick test as compared to SO and FO single treatments. Conclusively, our results suggest that the combination of both oils (SO+FO) exhibited significant antioxidant and analgesic potential that it could be considered as one of the active combinations for relieving pain in adjunctive treatment for joint pain associated with rheumatoid arthritis. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Polyunsaturated fatty acids en_US
dc.subject sesame oil en_US
dc.subject fish oil en_US
dc.subject analgesic activity en_US
dc.subject antioxidant activity en_US
dc.subject rheumatoid arthritis en_US
dc.title Comparative antioxidant and analgesic effect of sesame oil, fish oil and their combination in experimental animal model en_US
dc.type Article en_US


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