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Reduced antioxidant and anti-inflammatory effects of propofol at high-dose on morbidly obese patients

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dc.contributor.author Li, Jing
dc.contributor.author Li, Jia-Yang
dc.contributor.author Wu, Zhufeng
dc.contributor.author Peng, Xuemei
dc.date.accessioned 2022-10-27T10:43:54Z
dc.date.available 2022-10-27T10:43:54Z
dc.date.issued 2021-03-10
dc.identifier.citation Li, J., Li, J. Y., Wu, Z., & Peng, X. (2021). Reduced antioxidant and anti-inflammatory effects of propofol at high-dose on morbidly obese patients. Pakistan Journal of Pharmaceutical Sciences, 34(2), 561-566. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13805
dc.description.abstract This study was aimed to investigate differences in antioxidant and anti-inflammatory effects of propofol at two commonly used dosing schedules on morbidly obese patients. Twenty-two morbidly obese patients were randomly divided into two groups, namely, TBW (dosing based on total body weight) and LBW (dosing based on lean body weight) groups. Three biomarkers, i.e. superoxide dismutase (SOD), malondialdehyde (MDA) and nitric oxide (NO) were measured as indicators of the level of oxidation stress reaction. Pro-inflammatory cytokines including Interleukin-6 (IL-6) and Interleukin-8 (IL-8) were used to describe the degree of inflammation. Plasma levels of SOD, MDA and NO were increased and reached a peak value 0.5h after anesthesia induction, but the increase was smaller in the LBW group compared with the TBW group. Besides, plasma concentrations of IL-6 and IL-8 were also increased and attained a peak level 0.5h after anesthesia induction, but the increase was higher in the TBW group compared with the LBW group. The LBW-based dosing of propofol had more potent antioxidant and anti-inflammatory effects than the TBW-based dosing during anesthesia induction period on morbidly obese patients. This study provided a dosing recommendation of propofol for morbidly obese patients. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Propofol en_US
dc.subject morbidly obese en_US
dc.subject antioxidant en_US
dc.subject anti-Inflammatory en_US
dc.subject lean bodyweight en_US
dc.subject total body weight en_US
dc.title Reduced antioxidant and anti-inflammatory effects of propofol at high-dose on morbidly obese patients en_US
dc.type Article en_US


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