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A research on the mechanism of NSAID-related gastric ulcer treated by jia wei wu qi san based on the p38mapk signal pathway

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dc.contributor.author Zheng, Liang
dc.contributor.author Wang, Pei
dc.contributor.author Wang, Yuan-Yuan
dc.contributor.author Li, Zhen
dc.contributor.author Tian, Ye
dc.date.accessioned 2022-10-27T10:44:25Z
dc.date.available 2022-10-27T10:44:25Z
dc.date.issued 2021-03-13
dc.identifier.citation Zheng, L., Wang, P., Wang, Y. Y., Li, Z., & Tian, Y. (2021). A research on the mechanism of NSAID-related gastric ulcer treated by jia wei wu qi san based on the p38mapk signal pathway. Pakistan Journal of Pharmaceutical Sciences, 34(2), 585-590. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13808
dc.description.abstract This study aims to explore the mechanism of NSAID-related gastric ulcer treated by JIA WEI WU QI SAN. Clean-grade SD rats were randomly divided into four groups. Group A was assigned as the control group. Groups B, C and D were intragastrically administered with 2.5mg/kg of indomethacin solution QD after 48 hours. After 15 days of treatment, group B was administered with 0.9% sodium chloride, group C was given rabeprazole (2mg/kg), and group D was administered with JIA WEI WU QI SAN (2g/kg). Abdominal aorta sampling was performed, and gastric tissues were isolated on the 29th day. The protein expression of p-P38MAPK and COX-2 were detected by western blot, while the concentration of PGE2 and IL-1 were determined by ELISA. (1) The expression of IL-1ingroup B dramatically declined in group D (P<0.01). (2)The expression of PGE-2dramatically increased in group D(P<0.01). (3) The expression of COX-2 increased in group D (P<0.05). (4) The expression of p-P38MAPK decreased in group D (P<0.05). JIA WEI WU QI SAN has multiple functions, including the activation of the p-P38MAPK signaling pathway, which promote the activation of COX-2, induce the arachidonic acid to increase the level of PG, and decrease the concentration of IL-1, thereby inducing an inflammatory reaction, and promote gastric mucosa repair. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Flavored Wu Qi powder en_US
dc.subject nonsteroidal anti-inflammatory drugs (NSAIDS) en_US
dc.subject P-38 mapk signaling pathway en_US
dc.title A research on the mechanism of NSAID-related gastric ulcer treated by jia wei wu qi san based on the p38mapk signal pathway en_US
dc.type Article en_US


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