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Protective role of coffee supplementation in liver cirrhosis: Study in rats

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dc.contributor.author Nuzhat Fatima Zaidi, Syeda
dc.contributor.author Madni, Muhammad
dc.date.accessioned 2022-10-27T10:44:33Z
dc.date.available 2022-10-27T10:44:33Z
dc.date.issued 2021-03-14
dc.identifier.citation Zaidi, S. N. F., & Madni, M. (2021). Protective role of coffee supplementation in liver cirrhosis: Study in rats. Pakistan Journal of Pharmaceutical Sciences, 34(2). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13809
dc.description.abstract Present study was designed to evaluate the effects of coffee on liver function tests and liver antioxidant enzymes in thioacetamide induced liver cirrhosis in rats. Experimental study period was consisted of eighteen weeks divided into two phases. Therefore 24 rats were distributed randomly into four groups (n=6). Group I served as control. In phase I, group II and III received thioacetamide (200mg/kg body weight intraperitoneally twice a week) and group IV received saline for 12 weeks. In phase II, group II received saline while group III and IV received an oral dose of coffee (0.4mg/Kg b.w) daily for 6 weeks. At the end of the study period rats were sacrificed and blood was collected to get serum and liver was homogenized for the determination of antioxidant enzymes. Marked increase in serum total and direct bilirubin, ALT, AST whereas reduced ALP was observed in test group. The reduced tissue SOD activity and increased tissue catalase and tissue MDA activity were also observed in test group. However, coffee consumption in group III in phase II significantly restored liver biomarkers and the tissue antioxidant enzymes SOD, catalase and MDA activities. In conclusion, thioacetamide induced liver cirrhosis can be prevented by coffee supplementation. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Coffee en_US
dc.subject thioacetamide en_US
dc.subject liver cirrhosis en_US
dc.subject liver function tests en_US
dc.subject antioxidant enzymes en_US
dc.title Protective role of coffee supplementation in liver cirrhosis: Study in rats en_US
dc.type Article en_US


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