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Alkaloid and phenolic compounds of Xylopia aromatica inhibits tumor growth by down-regulating matrix metalloproteinase-2 (MMP-2) expression

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dc.contributor.author Natalia Faria Gomes, Izabela
dc.contributor.author Gabriela Silva, Ana
dc.contributor.author Fernando de Frazao Lima, Gustavo
dc.contributor.author Longatti, Ribeiro
dc.contributor.author Fernandes Do Carmo, Lucas
dc.contributor.author Ferreira Perez Villar, Augusto
dc.contributor.author Aparecida Da Costa Araujo, Arali
dc.contributor.author Gruppi Tome, Ralph
dc.contributor.author Dos Santos, Batista
dc.contributor.author Iara Maciel De Azambuja Ribeiro, Rosy
dc.date.accessioned 2022-10-27T10:44:41Z
dc.date.available 2022-10-27T10:44:41Z
dc.date.issued 2021-03-15
dc.identifier.citation Faria Gomes, I. N., Gabriela Silva, A., de Frazao Lima, G. F., Ribeiro Longatti, T., Fernandes Do Carmo, L., Ferreira Perez Villar, J. A., ... & De Azambuja Ribeiro, R. I. M. (2021). Alkaloid and phenolic compounds of Xylopia aromatica inhibits tumor growth by down-regulating matrix metalloproteinase-2 (MMP-2) expression. Pakistan Journal of Pharmaceutical Sciences, 34(2). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13810
dc.description.abstract Annonacea species have been reported to possess antitumor properties. However, the in vitro and in vivo antitumor activities of Xylopia aromatica (Annonacea) have not yet been elucidated. This study aimed to investigate the effects of Xylopia aromatica leaves hexane fraction (XaHF) on Ehrlich ascites carcinoma cells lines (EAC), both in vitro and in vivo. In vitro assays revealed a significant cytotoxic effect with the two lower XaHF concentrations (62.5 and 32.3mg/mL). EAC (2.5x106 cells) were inoculated in the right flank of Swiss mice, and the animals were treated intraperitoneally with 32.3mg kg−1 of XaHF daily, for 20 days. Our findings indicate that XaHF suppressed the growth of EAC in vivo, with a significant decrease (46%) in tumor volume. There was also a decrease in the necrosis area (71%), inflammatory infiltrate, and MMP-2 expression. High-Performance Liquid Chromatography with Diode Array Detector (HPLC- DAD) identified secondary metabolites possibly related to phenolic acids, flavonoids, and alkaloids. Thus, the results confirmed the antitumoral activity that may be related to the presence of the identified metabolites in XaHF extract en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Ehrlich tumor en_US
dc.subject matrix metalloproteinase en_US
dc.subject secondary metabolites en_US
dc.subject medicinal plants en_US
dc.subject antitumoral activity en_US
dc.title Alkaloid and phenolic compounds of Xylopia aromatica inhibits tumor growth by down-regulating matrix metalloproteinase-2 (MMP-2) expression en_US
dc.type Article en_US


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