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Dose related acute behavioral and neurochemical profile of pioglitazone

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dc.contributor.author Ikram, Huma
dc.contributor.author Abdul Sheikh, Shehnaz
dc.contributor.author Jabeen Haleem, Darakhshan
dc.contributor.author Ganau, Mario
dc.contributor.author Maqsood Choudhry, Adnan
dc.date.accessioned 2022-10-27T10:45:01Z
dc.date.available 2022-10-27T10:45:01Z
dc.date.issued 2021-03-17
dc.identifier.citation Ikram, H., Sheikh, S. A., Haleem, D. J., Ganau, M., & Choudhry, A. M. (2021). Dose related acute behavioral and neurochemical profile of pioglitazone. Pakistan Journal of Pharmaceutical Sciences, 34(2). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13812
dc.description.abstract Diabetics are twice as likely to have depression. It's normal to have long periods of sadness and anxiety. Pioglitazone has important role in the inflammatory response, which suggests that it might have the associated antidepressant effects being manifested by its anti-depressant profile which needs further exploration. Monitoring changes in behavioral and neurochemical profile of pioglitazone in a dose-dependent manner was the purpose of this study. Pioglitazone was injected to rats at the doses of 0mg/kg, 2.5mg/kg, 5mg/kg and 10mg/kg. Behavioral activities in open field, Skinner’s box and elevated plus maze were monitored 20, 35 and 45 minutes respectively after pioglitazone injection. whole brain samples were collected following decapitation of rats one-hour after injection. Samples were kept at -70ºC till HPLC-EC analysis for neurochemical profile. Results show anxiogenic and sedative effects of pioglitazone at all three doses as indicated by Skinner’s box, elevated plus maze activity and open field. Also there was an overall decreased dopamine metabolism and increased serotonin turnover. This suggests that diabetic patients using pioglitazone as a therapeutic option, may experience more potent effects of CNS depressants. Findings may help in extending therapeutics in diabetic patients suffering from anxiety and/or depression. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Pioglitazone en_US
dc.subject depression en_US
dc.subject anxiety en_US
dc.subject serotonin en_US
dc.subject dopamine en_US
dc.title Dose related acute behavioral and neurochemical profile of pioglitazone en_US
dc.type Article en_US


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