PASTIC Dspace Repository

Antimicrobial and antioxidant activity of catechin-3-o-rhamnoside isolated from the stem bark of Lannea kerstingii Engl. and K. Krause (Anacardiaceae)

Show simple item record

dc.contributor.author Ngaitad Stanislaus, Njinga
dc.contributor.author Mohammed Ibrahim, Sule
dc.contributor.author Umar Usman, Pateh
dc.contributor.author Halimatu, Hassan
dc.contributor.author Sa’adiya, Sa’adiya
dc.contributor.author Garba, Mohammed
dc.contributor.author Toyin, Sa’ad
dc.contributor.author Taibat Moji, Bakare-Odunola
dc.contributor.author Roland Ndifor, Ache
dc.contributor.author Godshelp Osas, Egharevba
dc.contributor.author Abiodun Oyetunji, Shittu
dc.contributor.author Muritala Salawu, Salawu
dc.date.accessioned 2022-10-27T10:45:23Z
dc.date.available 2022-10-27T10:45:23Z
dc.date.issued 2021-03-19
dc.identifier.citation Stanislaus, N. N., Ibrahim, S. M., Usman, P. U., Sa'adiya, H. H., Garba, M. M., Toyin, A. S. A., ... & Salawu, S. M. (2021). Antimicrobial and antioxidant activity of catechin-3-o-rhamnoside isolated from the stem bark of Lannea kerstingii Engl. and K. Krause (Anacardiaceae). Pakistan Journal of Pharmaceutical Sciences, 34(2). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13814
dc.description.abstract Various epidemiological researches have shown that consumption of vegetables and fruits are essential to maintain health and prevent diseases but the emergence of more and more drug resistance bacteria has led to high mortality. Thus the study of the antimicrobial and antioxidant activities of a flavonoid (Catechin-3-o-rhamnoside) isolated for the first time from Lannea kerstingii. Catechin-3-o-rhamnoside was isolated using dry vacuum liquid chromatography. It was characterized using 1H-NMR, 13C-NMR and 2D NMR spectra. The antimicrobial activity was determined using agar diffusion and broth dilution method. Antioxidant activity was determined through reaction of the compound with DPPH radical. The compound was active against, Methicillin Resistant Staphylococcus aureus, S. aureus, B. subtilis, E. coli, K. pneumoniae, S. typhi, S. dysentariae, C. albicans and C. tropicalis with zone of inhibition ranging from 22.0±0.1 to 35.0±0.2mm and inactive against vancomycin resistant enterococci, Proteus mirabilis and C. ulcerans. The MIC ranged from 6.25 to 12.5μg/ml while the MBC/MFC ranged from 12.5 to 50.0μg/ml. The compound showed a high radical scavenging activity with EC50 of 46.87µg/ml. These results show a potential lead drug for resistant bacteria and natural antioxidants. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Catechin-3-o-rhamnoside en_US
dc.subject Lannea kerstingii en_US
dc.subject antioxidant en_US
dc.subject antimicrobial en_US
dc.title Antimicrobial and antioxidant activity of catechin-3-o-rhamnoside isolated from the stem bark of Lannea kerstingii Engl. and K. Krause (Anacardiaceae) en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account