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Protective effect of Phaeoporus obliquus polysaccharide against acute liver injury induced by carbon tetrachloride and alcohol in mice

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dc.contributor.author Lei, Zhang
dc.contributor.author Xiao-hong, Ren
dc.contributor.author Jing, He
dc.contributor.author Wan-nan, Li
dc.contributor.author Jing-wei, Hao
dc.contributor.author Yun-rong, Jing
dc.contributor.author Jun-rong, Chai
dc.contributor.author Xiao-wei, Sun
dc.contributor.author Chun-lei, Wan
dc.date.accessioned 2022-10-27T10:45:39Z
dc.date.available 2022-10-27T10:45:39Z
dc.date.issued 2021-03-22
dc.identifier.citation Lei, Z., Xiao-Hong, R., Jing, H., Wan-Nan, L., Jing-Wei, H., Yun-Rong, J., ... & Chun-Lei, W. (2021). Protective effect of Phaeoporus obliquus polysaccharide against acute liver injury induced by carbon tetrachloride and alcohol in mice. Pakistan Journal of Pharmaceutical Sciences, 34(2). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13816
dc.description.abstract Studied the optimum extraction process of polysaccharide from Phaeoporus obliquus and the effect of Phaeoporus obliquus polysaccharide on carbon tetrachloride (CCl4)- or alcohol-induced acute liver injury in mice. The main factor in influencing the extraction rate of Phaeoporus obliquus polysaccharide were extraction power and time, which was a kind of pyran glucose by infrared spectroscopy. CCl4 and alcohol were employed respectively to establish CCl4 and alcohol-induced acute liver injury mouse models. Compared with model groups mice, Phaeoporus obliquus polysaccharide treatment at the doses of 100mg/kg and 200mg/kg exhibited an obvious reduction liver index, ALP, ALT, AST levels, MDA content and TNF-α level (p<0.01) and SOD activity was increased, which was in a dosedependent manner. Compared with the model group, the necrosis degree of hepatocytes was obviously reduced and the small fat droplets were formed in some cytoplasm, especially in high dose group, which the liver cells recovered to the level of normal group. Rt-PCR results showed that the expression of CYP2E1 mRNA in liver tissues of Phaeoporus obliquus polysaccharide groups were significantly reduced, and the difference were statistically significant compared with the model group (p<0.05). These results demonstrated that Phaeoporus obliquus polysaccharide has significantly hepatoprotective effect on CCl4 and alcohol-induced acute liver injury in mice. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Phaeoporus obliquus polysaccharide en_US
dc.subject CCl4 en_US
dc.subject acute liver injury en_US
dc.subject alcohol en_US
dc.title Protective effect of Phaeoporus obliquus polysaccharide against acute liver injury induced by carbon tetrachloride and alcohol in mice en_US
dc.type Article en_US


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