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Investigation of gastric microbiota in patients with coronary atherosclerosis disease infected by Helicobacter pylori

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dc.contributor.author Qin, Heping
dc.contributor.author Wei, Tianling
dc.contributor.author Yi, Ping
dc.contributor.author Shi, Zhe
dc.contributor.author Wan, Min
dc.contributor.author Li, Wei
dc.contributor.author Xia, Yangchao
dc.contributor.author Luo, Yihui
dc.contributor.author Lian, Haiyan
dc.contributor.author Liu, Ning
dc.date.accessioned 2022-10-28T07:54:56Z
dc.date.available 2022-10-28T07:54:56Z
dc.date.issued 2021-11-07
dc.identifier.citation Qin, H., Wei, T., Yi, P., Shi, Z., Wan, M., Li, W., ... & Liu, N. (2021). Investigation of gastric microbiota in patients with coronary atherosclerosis disease infected by Helicobacter pylori. Pakistan Journal of Pharmaceutical Sciences, 34(6 (Special)), 2429-2435. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13838
dc.description.abstract Gastric microbiota may be involved in the pathogenicity of Helicobacter pylori(Hp). In the present study, 30 male patients with coronary atherosclerosis disease (CAD) infected with Hp and 30 healthy male volunteers with Hp infection as the control group were detectedby macrogenomic sequencing for gastric microbiota. According to the diversity of gastric microbiota, the CAD group was further divided into two subgroups: CAD treatment (CAD-T) and CAD fellow-up (CAD-F). Shannon index of CAD-T was significantly lower than that of the control group and CAD-F (P<0.05), Simpson index was significantly higher than that of the control group and CAD-F (P<0.05), and there was no statistical difference between CAD-T and the control group and CAD-F patients in Chao1 and ACE index (P>0.05). There is a difference in the dominant flora between the CAD group and the control group. After Hp eradication, Shannon index of gastric microbiota increased, Simpson index decreased, and there was statistical difference before and after Hp eradication in CAD-T group (P<0.05). There was no significant difference in Chao1 and ACE index between before and after Hp eradication (P>0.05). There is a significant difference in the dominant flora before and after eradication in CAD-T group. There were significant differences in clinical manifestations, endoscopic manifestations and pathological results among the three groups (P<0.05). The diversity of gastric microbiota is closely related to the pathogenicity of Hp,, regardless of dominant flora. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Helicobacter pylori en_US
dc.subject coronary atherosclerosis disease en_US
dc.subject gastric microbiota en_US
dc.subject gastroscopic displays en_US
dc.title Investigation of gastric microbiota in patients with coronary atherosclerosis disease infected by Helicobacter pylori en_US
dc.type Article en_US


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