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The effects of gamma-radiation on red blood cell corpuscles and dimensional properties in rats

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dc.contributor.author Anwar Kassem Abdelhalim, Mohamed
dc.contributor.author Suliman Al-Ayed, Mohammed
dc.contributor.author Abd El-Mottaleb Moussa, Sherif
dc.contributor.author Mohamed A. Al-Sheri, Abd El-Hadi
dc.date.accessioned 2022-10-28T07:59:59Z
dc.date.available 2022-10-28T07:59:59Z
dc.date.issued 2015-09-01
dc.identifier.citation Abdelhalim, M. A., Al-Ayed, M. S., Moussa, S. A., & Al-Shehri, A. E. (2015). The effects of gamma-radiation on red blood cell corpuscles and dimensional properties in rats. Pak. J. Pharm. Sci, 28(5), 1819-1822. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13847
dc.description.abstract In an attempt to understand the toxicity and the potential role of gamma-radiation as a therapeutic tool, the effects of different Gamma-radiation doses on haematological and dimensional properties of rats’ blood were investigated in vivo. 60 healthy male Wistar-Kyoto rats were used, which were randomly divided into five groups, 4 Gamma-radiated rat groups (1st group was radiated with five Gamma-radiation dose, 2nd group 25Gy; 3rd group with 50Gy, 4th group with 100Gy, and 5th group was control). Different haematological and dimensional parameters were measured using the standard haematological technique. A significant decrease in red blood cells (RBCs) count, haemoglobin (HGB), and haematocrit (HCT) was observed compared with the control. While a significant increase in mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC), red distribution width (RDW) were observed compared with the control. This study suggested that low RBCs, HGB, and HCT might produce anemia and cessation of erythrocytes production in the bone marrow. Moreover, the RBCs size increase might be attributed to changes in the morphology and deformability of RBCs, which was confirmed by a slightly increase in RDW. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Gamma-radiation en_US
dc.subject In-vivo en_US
dc.subject RBCs en_US
dc.subject HGB en_US
dc.subject HCT en_US
dc.subject MCV en_US
dc.subject MCH en_US
dc.subject MCHC en_US
dc.subject RDW en_US
dc.title The effects of gamma-radiation on red blood cell corpuscles and dimensional properties in rats en_US
dc.type Article en_US


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