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Effects of smokeless dipping tobacco (Naswar) consumption on antioxidant enzymes and lipid profile in its users

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dc.contributor.author Sajid, Faiza
dc.contributor.author Bano, Samina
dc.date.accessioned 2022-10-28T08:00:09Z
dc.date.available 2022-10-28T08:00:09Z
dc.date.issued 2015-09-03
dc.identifier.citation Sajid, F., & Bano, S. (2015). Effects of smokeless dipping tobacco (Naswar) consumption on antioxidant enzymes and lipid profile in its users. Pak J Pharm Sci, 28(5), 1829-1833. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13848
dc.description.abstract Dipping tobacco, traditionally referred to as moist snuff, is a type of finely ground, moistened smokeless tobacco product. Naswar is stuffed in the floor of the mouth under the lower lip, or inside the cheek, for extended periods of time. Tobacco use causes dyslipidemia and also induces oxidative stress, leading to alteration in levels of antioxidant enzymes. Dyslipidemia and oxidative stress in turn play a vital role in the development of cardiovascular disease (CVD). Studies conducted on smokeless tobacco products reveal contradictory findings regarding its effects on lipid profile and antioxidant enzymes. As use of Naswar is quite common in Pakistan, the current study aimed to evaluate levels of the antioxidant enzymes viz glutathione per oxidase (GPx) and super oxide dismutase (SOD), alongside lipid profile parameters such as total cholesterol, triglycerides, High density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) to assess the risk of adverse cardiovascular events in Naswar users.90Healthy males aged 16-43 years, who consumed Naswar daily, were selected for the study, alongside 68 agematched non-tobacco users as controls. Both GPx and SOD levels as well as serum HDL-C were significantly reduced (P<0.01) in Naswar users, whereas serum total cholesterol, LDL-C, triglycerides and LDL-C/HDL-C ratio were significantly increased (P<0.01) in Naswar consumers compared to controls. Our findings indicate deleterious effects of Naswar usage on health by causing altered lipid profile and antioxidant enzymes thereby placing its consumers at an increased risk of cardiovascular disease. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Smokeless dipping tobacco en_US
dc.subject Naswar en_US
dc.subject glutathione per oxidase en_US
dc.subject super oxide dismutase en_US
dc.subject lipid profile en_US
dc.title Effects of smokeless dipping tobacco (Naswar) consumption on antioxidant enzymes and lipid profile in its users en_US
dc.type Article en_US


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