PASTIC Dspace Repository

Preparation, characterization and in vivo evaluation of pharmacological activity of different crystal forms of ibuprofen

Show simple item record

dc.contributor.author Li, Yanxiang
dc.contributor.author Yao, Feng
dc.contributor.author Shang, Chenxu
dc.contributor.author Ren, Feng
dc.contributor.author Zhang, Jiye
dc.contributor.author Li, Yanan
dc.contributor.author Yang, Guangde
dc.contributor.author Lin, Rong
dc.contributor.author Wang, Weirong
dc.date.accessioned 2022-10-28T08:03:28Z
dc.date.available 2022-10-28T08:03:28Z
dc.date.issued 2019-09-18
dc.identifier.citation Li, Y., Yao, F., Shang, C., Ren, F., Zhang, J., Li, Y., ... & Wang, W. (2019). Preparation, characterization and in vivo evaluation of pharmacological activity of different crystal forms of ibuprofen. Pakistan Journal of Pharmaceutical Sciences, 32(5). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13854
dc.description.abstract Different polymorphic forms can affect the performance of the drug product. In addition, isomorphic crystals show different chemical and physical properties due to the changes in the crystal habit. However, it is unclear whether the crystal habit results in different pharmacological activity. The aim of this study was to investigate whether the pharmacological effect of ibuprofen could be affected due to the variety of the crystal habit. Solvent change technique and conventional fusion method were carried out to modify the characteristics of ibuprofen. The physicochemical properties of each were investigated using powder X-ray diffraction (PXRD), Fourier transform infrared (FT-IR) spectroscopy and differential scanning calorimetry (DSC) techniques. Results of scanning electron microscopy (SEM) analysis revealed differences in the surface characteristics of the crystals obtained. Further study revealed that the samples crystallized exhibited the remarkable variation on the dissolution profiles in different dissolution medium. Moreover, in vivo antinociceptive and anti-inflammatory findings demonstrated that the crystal habit modifications resulted in the different therapeutic efficacy. Taken together, these results indicate that the modification of the crystal habit had a great influence on the in vivo pharmacological activity of ibuprofen crystals en_US
dc.language.iso en_US en_US
dc.subject Crystal habit en_US
dc.subject dissolution test en_US
dc.subject antinociceptive activity en_US
dc.subject anti-inflammatory activity en_US
dc.subject ibuprofen. en_US
dc.title Preparation, characterization and in vivo evaluation of pharmacological activity of different crystal forms of ibuprofen en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account