Abstract:
This study was aimed to investigate the dermal irritant test and the central analgesic effects of topical
application of seven different formulations (A-G) of analgesic gel prepared from locally available raw material in animal
model. The results of dermal irritant test revealed that no animal showed any kind of toxic effect i.e. redness, irritation,
itching, inflammation, skin infection or any other injurious effects. All animals remained healthy, active, alert showing
normal behavior and no mortality was observed during the claimed period. The analgesic activity was performed by tail
flick test. The analgesic activity against tail flick test revealed that all samples of test gel had analgesic effect at 15, 30
and 60 minutes after sample application but sample D had highest analgesic effects (193%) followed by sample E
(155%), sample C (122%), sample G (85%), sample B (84%),sample F (81%) while sample A exhibited (73%) analgesic
activity. Wintogeno was run as standard drug and it showed 168% analgesic activity.
