Volume30: Recent submissions

  • Pharmacokinetic and bioequivalence studies of fast dispersible ketoprofen tablets in healthy volunteers 
    Farya Zafar; Shoaib, Muhammad Harris; Yousuf, Rabia Ismail; Huma Ali; Rabia Bushra (Karachi: Pakistan Botanical Society, University of Karachi, 2017-07-20)
    In the present study the pharmacokinetic and bioequivalence parameter of Ketoprofen 100 mg fast dispersible tablets (test) were measured with marketed (reference) product. This study was accomplished following FDA guidance. ...
  • Tumor necrosis factor-α and procalcitonin level variations in the serum and their effects on organ function in patients with severe acute pancreatitis during infected stage 
    Zhu, Yanping (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-07-03)
    To investigate the changes of tumor necrosis factor-α (TNF-α) and procalcitonin (PCT) in the serum and their effects on organ function in patients with severe acute pancreatitis (SAP) during infected stage, aiming to ...
  • Antiviral screening of four plant extracts against acyclovir resistant herpes simplex virus type-1 
    Masoud Parsania; Mohammad-Bagher Rezaee; Seyed Hamidreza Monavari; Kamkar Jaimand; Seyed Milad Mousavi-Jazayeri; Mehdi Razazian; Mohammad Hossein Nadjarha (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-07-02)
    Herpes simplex virus type 1 (HSV-1) causes serious infections particularly in immunocompromised patients. Methanolic extract of four plants were evaluated for their anti-viral effects against acyclovir resistant HSV-1 in ...
  • Heavy metals identification and exposure at workplace environment its extent of accumulation in blood of iron and steel recycling foundry workers of Lahore, Pakistan 
    Riaz, Muhammad Ahsan; Akhtar, Amtul Bari Tabinda; Ayesha Riaz; Ghulam Mujtaba; Muhammad Ali; Beenish Ijaz (Karachi: Pakistan Botanical Society, University of Karachi, 2017-07-20)
    The determination of heavy metals in blood is an important occupational environmental toxicology screening procedure. The aim of study was to determine the concentrations of Pb, Cd, Cr and Ni in blood samples of iron and ...
  • Effects of estrogen on learning-memory and expression of calbindinD28K in hippocampus in vascular dementia rats 
    Li, Jing; Zhang, Lei; Li, Jiao-Jiao; Xian-Qu; Chen, Lin; Li, Dong-Ying; Li, Chun-Ying (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-07-01)
    Vascular dementia (VD) models were made first by repeating cerebral ischemia-reperfusion and followed by treating with estrogen. Learning-memory ability was measured by Morris water maze. Concentration of Ca2+ in hippocampus ...
  • Enhancing the in vitro release of total flavonoids extract from Dracocephalum moldavuca composite phospholipid liposomes optimized by response surface methodology 
    Cheng Zeng; Guipeng Xue; Xiaoyi Yang; Chenghui He; Wei Huang; Jianguo Xing (Karachi: Pakistan Botanical Society, University of Karachi, 2017-07-20)
    The present study was undertaken to optimize the preparation conditions of total flavonoids extract from Dracocephalum Moldavuca composite phospholipid liposome (TFDMCPL) by response surface methodology (RSM) and to ...
  • Progression pattern of rheumatoid arthritis: A study of 500 Pakistani patients 
    Fazal Jalil; Maria Arshad; Attya Bhatti; Muhsin Jamal; Mushtaq Ahmed; Malik, Javaid Mehmood; Sajid Ali; Fazal Akbar; Peter John (Karachi: Pakistan Botanical Society, University of Karachi, 2017-07-20)
    To estimate the most prevalent age of patients and disease status and progression in terms of severity at different age groups in the Pakistani Rheumatoid Arthritis (RA) patients. A total of five hundred (500) RA patients ...
  • In vivo anti-inflammatory and anti-platelet aggregation activities of longissiminone A, isolated from Usnea longissima 
    Azizuddin; Saima Imran; Choudhary, Muhammad Iqbal (Karachi: Pakistan Botanical Society, University of Karachi, 2017-07-20)
    Secondary metabolite, longissiminone A (1) was isolated from a lichen, Usnea longissima. It was screened for its’ in vivo anti-inflammatroy and anti-platelet aggregation activities. Compound 1 showed moderate in vivo ...
  • Prevention of liver cirrhosis by Silymarin 
    Zaidi, Syeda Nuzhat Fatima; Tabassum Mahboob (Karachi: Pakistan Botanical Society, University of Karachi, 2017-07-20)
    This study was designed to evaluate the effects of sylimarin supplementation on different biochemical parameters in thioacetamide induced cirrhotic rats. For this purpose 24 male Albino wistar rats were divided into four ...
  • Effects of puerarin on lipopolysaccharide-induced myocardial dysfunction in isolated rat hearts 
    Zhang Shaojun; Xu Yanyan; Chen Jian; Zheng Xia; Fang qiang; Jiang Saiping (Karachi: Pakistan Botanical Society, University of Karachi, 2017-07-20)
    Myocardial dysfunction is a serious complication induced by sepsis. Puerarin is an oriental medicine that possesses therapeutic benefits for cardiovascular diseases. The aim of this study was to evaluate the anti-myocardial ...
  • Pharmacokinetic behavior of montelukast in indigenous healthy male volunteers 
    Fayyaz, Amtul; Khan, Junaid Ali; Ashraf, Muhammad Mudassar; Akhter, Naheed; Aslam, Bilal; Khalid, Muhammad Fiaz; Altaf, Sidra; Naseer, Rana Dawood; Akram, Muhammad; Shah, Syed Muhammad Ali; Khadam, Muhammad Waqas; Tahir, Imtiaz Mahmood (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-18)
    Aim of present study was to investigate the pharmacokinetic behavior of Montelukast in the healthy male volunteers under indigenous conditions. One tablet of montelukast 10 mg was administered in each subject and blood ...
  • Notch1 signaling activation protected myocardium against hypoxia injury via reducing programmed cell death 
    Hu, Yongjun; Zheng, Zhaofen; Pan, Hongwei; Peng, Jianqiang; Luo, Yangping; Cui, Bo; Zhong, Xin (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-17)
    Programmed cell death plays an important role in cardio protection, and Notch1 was an important factor related to programmed cell death. The role of Notch1 on ischemia myocardium remains unclear.H9C2 myocardial cells were ...
  • Dizocilpine induced psychosis-like behavior in rats: A possible animal model with full spectrum of schizophrenia 
    Shahzad, Sidrah; Ahmad, Saara; Madiha, Syeda; Khaliq, Saima; Liaquat, Laraib; Sadir, Sadia; Rafiq, Sahar; Tabassum, Saiqa; Batool, Zehra; Haider, Saida (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-16)
    Schizophrenia (SZ) is categorized as neuropsychiatric disorder with reduced lifespan and significant impairments in social and vocational functioning. One of the best proposed pharmacological animal models is dizocilpine, ...
  • MRSA: Prevalence and susceptibility pattern in health care setups of Karachi 
    Siddiqui, Tuba; Muhammad, Iyad Naeem; Khan, Muhammad Naseem; Naz, Shazia; Bashir, Lubna; Sarosh, Nosheen; Masood, Rida; Ali, Aatka; Fatima, Sakina; Naqvi, Talat (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-15)
    This assessment aims to determine the prevalence of methicillin resistance and multidrug resistance (MDR) among the clinical isolates of Staphylococcus aureus and antimicrobial susceptibility profile of methicillin resistant ...
  • Cytotoxic and acute toxicity studies of isoniazid derivatives 
    Naeem, Sabahat; Akhtar, Shamim; Lei, Zi-Ning; Lu, Kimberly; Zafar, Shaista; Ahmed, Ahsaan; Ali, Mohsin; Ahmed, Mansoor; Chen, Zhe-Sheng (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-14)
    Cancer is ultimately the result of cells that hysterically grow and do not die. Cells can experience uncontrolled growth if there are mutations to DNA, and therefore, alterations to the genes involved in cell division. ...
  • The role of Glutathione, Cysteine and D-Penicillamine in exchanging Palladium and Vanadium metals from albumin metal complex 
    Mukhtiar, Muhammad; Jan, Syed Umer; Ullah, Ihsan; Hussain, Abid; Ullah, Izhar; Gul, Rahman; Ali, Essa; Jabbar, Abdul; Kuthu, Zulfiqar Hussan; Wasim, Muhammad; Khan, Muhammad Farid (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-13)
    Thiol groups are extensively present across biological systems being found in range of small molecules (e.g. Glutathione, Homo-cysteine) and proteins (e.g. albumin, haemo-globin). Albumin is considered to be a major thiol ...
  • Metal complexes of isonicotinylhydrazide and their antitubercular activity 
    Ali, Mohsin; Ahmed, Mansoor; Hafiz, Saleem; Kamal, Mustafa; Mumtaz, Majid; Hanif, Muhammad; Khan, Khalid Mohammed (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-12)
    The development and spreading of Multi Drug Resistant TB strains is hampering endeavours for the control and administration of tuberculosis (TB). The expansion episodes of multi-medication safe strains of Mycobacterium ...
  • Isolation and characterization of antibiotic producing bacterial strains from red soil of Himalayan region of Pakistan 
    Uzair, Bushra; Firdous, Neelam; Khan, Barkat Ali; Khan, Samiullah; Fatima, Sammer; Kausar, Rehana; Bano, Asma (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-11)
    The emergence of multi drug resistant microbial pathogens has become a global health challenge and set a dire requirement of searching new effective antimicrobials. Soil is an ultimate reservoir of biologically active micro ...
  • Biologically active compounds from the red sea sponge Suberea sp. 
    Shaala, Lamiaa A; Almohammadi, Ameen (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-10)
    Investigation of the cytotoxic fraction of the extracts of the Red Sea sponge Suberea sp. resulted in the identification of two new compounds, 1-(hydroxy(1H-pyrrol-2-yl)methyl)guanidine and 4-(2-amino-3-methylbut-3-en-1-yl)phenol ...
  • Sorafenib tosylate, Ribavirn and Sofosbuvir combination therapy for HCV virus infected patients with decompensated liver cancer 
    Munir, Bushra; Ahmed, Bilal; Kiran, Shumaila; Jalal, Fatima; Zahoor, Muhammad Kashif; Shehzadi, Saba; Oranab, Sadaf; Kamran, Sayed Kashif Shahid; Ghaffar, Abdul (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-09)
    : Hepatitis C is the most common health problem worldwide and is major cause of death due to proliferation of hepatocellular carcinoma. The medicines available for HCV treatment overcome up-to 95% complications of HCV. ...

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