Volume30: Recent submissions

  • Enriched environment palliates nicotine-induced addiction and associated neurobehavioral deficits in rats 
    Nawaz, Amber; Batool, Zehra; Ahmed, Saara; Tabassum, Saiqa; Khaliq, Saima; Mehdi, Bushra Jabeen; Sajid, Irfan; Ahmad, Shoaib; Saleem, Sadia; Naqvi, Fizza; Naqvi, Faizan; Haider, Saida (Enriched environment palliates nicotine-induced addiction and associated neurobehavioral deficits in rats, 2017-11-08)
    This study was designed to investigate the role of enriched environment in preventing and/or reducing the neurobehavioral deficits produced after nicotine administration in albino Wistar rats. Equal numbers of rat in two ...
  • HPLC and GC-MS: Identification and Quantification of Strychnine and Brucine in Strychnos nux-vomica leaves 
    Maddisetty, PN Prasad; Doss, VA; S, Mohanasundaram; V, Srinivasarao; T, Mohanbabu (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-07)
    In this study, we have aimed to analyze the phytochemical composition of this plant and the concentration of strychnine and brucine. The identification of bioactive compounds was done by GC-MS with NIST Library. Strychnine ...
  • The hepatoprotective effects of aquatic extract of Levisticum officinale against paraquat hepatocyte toxicity 
    Afarnegan, Hasan; Shahraki, Ali; Shahraki, Jafar (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-06)
    Paraquat is extensively used as a strong nitrogen-based herbicide for controlling weeds in agriculture. This herbicide is extremely toxic to humans and induces multiorgan failure due to accumulation in the cells. So far, ...
  • Chromatographic method development and validation for the determination of valsartan in biological fluid 
    Ghayas, Sana; Shoaib, Muhammad Harris; Siddiqui, Fahad; Yousuf, Rabia Ismail; Masood, M. Ali; Anjum, Fakhsheena; Bushra, Rabia; Bashir, Lubna; Naz, Shazia; Muhammad, Iyad Naeem (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-05)
    A swift, precise and simple HPLC bioanalytical technique with UV detection was established and validated for quantitative estimation of valsartan in human plasma. The analyte was separated from plasma by protein precipitation ...
  • Radiolabeling of benzylpenicillin with lutetium-177: Quality control and biodistribution study to develop theranostic infection imaging agent 
    Shahzad, Muhammad Adeel; Naqvi, Syed Ali Raza; Rasheed, Rashid; Yameen, Muhammad; Anjum, Fozia; Ahmed, Muhammad Tauqeer; Hussain, Zaib; Gillani, Syed Jawad Hussain (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-04)
    Benzylpenicillin acts through binding with beta-lactamase enzyme and inhibiting the bacterial cell wall biosynthesis. Therefore, the radiolabeling of benzylpenicillin with lutetium-177 is expected to serve as a theranostic ...
  • Development and validation of stability indicating assay method for cinitapride in bulk & tablets 
    Rehman, Atta-ur; Beg, Anwar Ejaz; Bushra, Rabia; Ashfaq, Maria; Zafar, Farya; Ali, Huma; Rizvi, Mehwish (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-03)
    A simple stability indicating UV-spectrophotometric method has been developed and validated for the determination of cinitapride hydrogen tartrate (CHT) in bulk and solid pharmaceutical dosage form. Drug absorption was ...
  • Larvicidal, pupicidal and adulticidal activities of non-polar solvent extract of Cymbopogon nardus (Linn.) whole plant against a mosquito, Culex quinquefasciatus (Say.) 
    Ilahi, Ikram; Yousafzai, Ali Muhammad (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-02)
    The present research is aimed to investigate the susceptibility of Cx. quinquefasciatus larvae (2nd and 4th instars), pupae and adults during exposure to various concentrations of C. nardus n-hexane extract. Increase in ...
  • Cross-linked guar gum and sodium borate based microspheres as colon-targeted anticancer drug delivery systems for 5-fluorouracil 
    Kamal, Tehsin; Sarfraz, Muhammad; Arafat, Mosab; Mikov, Momir; Rahman, Nisar-ur (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2017-11-01)
    The aim was to prepare cross linked polymer of 5-fluorouracil loaded microspheres containing guar gum and sodium borate for colon-targeted drug delivery systems. Micro spheres were prepared using emulsification cross ...
  • Ricinus cmmunis: Ethnomedicinal uses and pharmacological activities 
    Khan Marwat, Sarfaraz; ur-Rehman, Fazal; Ahmad Khan, Ejaz; Safdar Baloch, Mohammad; Sadiq, Muhammad; Ullah, Imdad; Javaria, Sadaf; Shaheen, Salma (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2017-10-09)
    Ricinus cmmunis L. (Castor oil plant) is an important medicinal plant belonging to family Euphorbiaceae. Its phytochemistry, biological and pharmacological activities, and ethnomedicinal uses have been reviewed in the ...
  • Lactic acid bacteria in traditional fermented Asian foods 
    Azam, Mariya; Mohsin, Mashkoor; Ijaz, Hira; Ruqia Tulain, Ume; Adnan Ashraf, Muhammad; Fayyaz, Ahad; ul Abadeen, Zain; Kamran, Qindeel (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2017-10-08)
    Lactic acid bacteria play vital roles in various fermented foods in Asia. This paper reviews many types of the world's lactic acid fermented foods and discusses the beneficial effects of lactic acid fermentation of food. ...
  • Antidiabetic effects of native date fruit Aseel (Phoenix dactylifera L.) in normal and hyperglycemic rats 
    Ahmed, Shadab; Alam Khan, Rafeeq; Jamil, Subia; Afroz, Syeda (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2017-10-07)
    Change in dietary pattern, sedentary life style and increasing stresses are contributing factors for high prevalence of diabetes mellitus. Diabetic complications often lead to cardiovascular diseases, hypertension and ...
  • Colonization rates and immune status of children against Streptococcus pneumoniae before the introduction of pneumococcal conjugate vaccine 
    Bibi, Safia; Ruba Siddiqui, Taranum; Furqan Hassan, Syed; Ahmed, Waquaruddin (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2017-10-06)
    Pneumococcal infections contribute to high morbidity and mortality in Pakistan. Pneumococcal colonization rates and immune status of children before and after vaccination can serve as an important indicator to determine ...
  • Screening of medicinally important Berberis lyceum for their antimicrobial activity by disc diffusion assay 
    Bakht, Jehan; Iftikhar, Zainab; Shafi, Mohammad; Iqbal, Arshad (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2017-10-05)
    The present research was focused on the anti-microbial activities of different solvent extracted fractions from commercial available and fresh plants of Berberis lyceum against Gram positive, Gram-negative bacteria and ...
  • Urease inhibitory activity of Hippophae rhamnoids and Cassia fistula 
    Ali Khan, Barkat; Akhtar, Naveed; Khan, Haroon; Mustafa, Ghulam; Rasul Niazi, Zahid; Menaa, Farid (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2017-10-04)
    The rational use of plants as medicine is traced back over five epochs to ancient documents of early civilizations and is certainly as old as mankind. These medicines originally developed from crude drugs like tinctures ...
  • Evaluation of dynamics of derivatization and development of RPHPLC method for the determination of amikacin sulphate 
    Shehzadi, Naureen; Hussain, Khalid; Tanveer Khan, Muhammad; Salman, Muhammad; Islam, Muhammad (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2017-10-03)
    The absence of chromophore and/or conjugated system, prerequisite for UV and florescent light detection, or absorbance at very low wavelength necessitates the development of simple and reliable methods for the determination ...
  • Bile acids and bile alcohols from Muraenesox bagio, Pomadasys argenteus and Lobeo rohita 
    Rasheed, Munawwer; Ahmed, Mansoor; Hassan, Amir; Nazim, Urooj; Alam Khan, Rafeeq; Kamal, Mustafa; Abdur Rashid, Mohammad (2017-10-02)
    Gallbladders bile of three well known commercial fish of South Asia region named Muraenesox bagio (locally called bam), Pomadasys argenteus (dother) and Lobeo rohita (rohu) were analysed on GC-MS, after derivatising the ...
  • Moxifloxacin reduces Stenotrophomonas maltophilia adhesion to mouse intestinal tract in vitro 
    Khadem Zgair, Ayaid; A Ghafil, Jenan; M. Radif, Hala; Naser Radhi, Shamim; H Hafiz, Mohammad; Fadhel Abbas Albaayit, Shaymaa (2017-10-01)
    Stenotrophomonas maltophilia is an important opportunistic pathogen that affects immunocompromised individuals. Viable bacterial count method was used to count the number of adhered bacteria. The current study showed the ...
  • In vitro antioxidant and antibacterial activity of various extracts from exocarps and endocarps of walnut 
    Zarghami Moghaddam, Parastoo; Mohammadi, Ameneh; Feyzi, Peyman; Alesheikh, Peiman (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2017-09-28)
    Juglans regia seed has been used in traditional medicines as antimicrobial, antihelmintic and anti-diarrhoeal. In the present study, the antibacterial capabilities dichloromethane, ethyl acetate, methanol and aqueous ...
  • Synthesis, enzyme inhibition and molecular docking studies of 1- Arylsulfonyl-4-phenylpiperazine derivatives 
    Athar Abbasi, Muhammad; Anwar, Ambreen; Rehman, Aziz-ur; Zahra Siddiqui, Sabahat; Rubab, Kaniz; Adnan Ali Shah, Syed; Arif Lodhi, Muhammad; Ali Khan, Farman; Ashraf, Muhammad; Alam, Umber (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2017-09-27)
    Heterocyclic molecules have been frequently investigated to possess various biological activities during the last few decades. The present work elaborates the synthesis and enzymatic inhibition potentials of a series ...
  • Evaluation of Artemisia scoparia for hemostasis promotion activity 
    Sajid, Moniba; Rashid Khan, Muhammad; Ali Shah, Naseer; Sher Waris, Tayyaba; Younis, Tahira; Ullah, Shafi; Ahmed, Nadeem (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2017-09-26)
    Excessive hemorrhage through any reasons is a life threatening process. Artemisia scoparia of family Asteraceae has been used in local system of medicine to stop bleeding from wounds and in injuries, antiseptic, in healing ...

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