PASTIC Dspace Repository

Effect of camel milk against renal toxicity in experimental rats

Show simple item record

dc.contributor.author Al-Asmari, Abdulrahman
dc.contributor.author Abbasmanthiri, Rajamohamed
dc.contributor.author Al-Elawi, Abdulrahman M
dc.contributor.author Horaib, Ghaleb Al
dc.contributor.author Sadoon, Khalid Al
dc.contributor.author Al-Asmari, Bayan
dc.date.accessioned 2022-11-03T10:09:31Z
dc.date.available 2022-11-03T10:09:31Z
dc.date.issued 2017-03
dc.identifier.citation Al-Asmari, A. K., Abbasmanthiri, R., Al-Elawi, A. M., Al-Horaib, G., Al-Sadoon, K., & Al-Asmari, B. A. (2017). Effect of camel milk against renal toxicity in experimental rats. Pakistan Journal of Pharmaceutical Sciences, 30. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13911
dc.description.abstract Most of the antibiotics are associated with considerable side effects. Gentamicin (GM) is one of the most commonly used antibiotics, but has significant nephrotoxic side effects. Hence, the current study is investigating the beneficial role of camel milk (CM) that ameliorate GM unwanted renal defects and dysfunctions in some experimental animals. Sprague-Dawely rats weighing (200-220g) were divided into groups (four) of six. Group 1 (Control) received normal saline (only). Group 2 was given oral administration of CM at the dose of 5ml/rat/day for fifteen days. Group 3 was injected with GM (80mg/kg b.wt., i.p.) for 10 days. Group 4 was first given oral administration of CM at the dose of 5ml/rat/day alone, for five days, and then followed with the administration GM for next 10 days, accordingly. The results show that administration of GM significantly enhanced the kidney weight and levels of renal toxicity markers like urea and creatinine, in addition to decreased levels of blood glucose. Treatment with CM ameliorated and reversed these drastic changes in levels of creatinine, urea and improved renal weight. Glucose levels were also reversed and increased significantly. Furthermore, GM induced renal histological anomalies like degeneration of glomeruli and tubules were suppressed by CM and showed better progress. The present study confirm that pretreatment with CM attenuates GM unwanted, induced renal dysfunction and cellular damage. en_US
dc.language.iso en_US en_US
dc.publisher Faculty of Pharmacy & Pharmaceutical Sciences en_US
dc.subject Gentamicin en_US
dc.subject camel milk en_US
dc.subject kidney en_US
dc.subject rats en_US
dc.subject toxicity en_US
dc.title Effect of camel milk against renal toxicity in experimental rats en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account