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Evaluation of three plant extracts against biofilm formation and expression of quorum sensing regulated virulence factors in Pseudomonas aeruginosa

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dc.contributor.author Karbasizade, Vajihe
dc.contributor.author Dehghan, Parichehr
dc.contributor.author Sichani, Maryam Mohammadi
dc.contributor.author Shahanipoor, Kahin
dc.contributor.author Sepahvand, Shahriar
dc.contributor.author Jafari, Reyhaneh
dc.contributor.author Yousefian, Rozita
dc.date.accessioned 2022-11-03T10:12:44Z
dc.date.available 2022-11-03T10:12:44Z
dc.date.issued 2017-03
dc.identifier.citation Karbasizade, V., Dehghan, P., Sichani, M. M., Shahanipoor, K., Sepahvand, S., Jafari, R., & Yousefian, R. (2017). Evaluation of three plant extracts against biofilm formation and expression of quorum sensing regulated virulence factors in Pseudomonas aeruginosa. Pakistan Journal of pharmaceutical sciences, 30. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13917
dc.description.abstract Following the increasing antibiotic resistance of pathogenic bacteria, the use of medicinal herbs as antibacterial agents has attracted growing attention. Pseudomonas aeruginosa is a human opportunistic pathogen that uses quorum sensing for regulating virulence gene expression (pyocyanin, protease, and elastase production and biofilm formation). This study examined the anti-quorum sensing activity of Quercus infectoria, Zataria multiflora and Trachyspermum copticum extracts on standard P. aeruginosa strain. The minimum inhibitory concentration (MIC) of Q. infectoria, Z. multiflora and T. copticum extracts for standard P. aeruginosa strain was determined through micro dilution. Microtiter plates were used to evaluate the anti-quorum sensing effects of the three extracts (at a sub-MIC concentration) on pyocyanin, protease, and elastase production and biofilm formation. The acetone extract of Q. infectoria showed the highest anti-quorum sensing activity and reduced the pyocyanin, protease, and elastase production and biofilm formation by 89.1%, 78%, 73.3%, and 70.1%, respectively. The corresponding values were 88.2%, 72.1%, 69%, and 61.1% for the methanol extract of Z. multiflora and 70.6%, 63.42%, 60.1%, and 59.1% for the methanol extract of T. copticum. Considering the high anti-quorum sensing activity of the studied extracts, especially the acetone extract of Q. infectoria, these herbs can be used as antipathogenic drugs. en_US
dc.language.iso en_US en_US
dc.publisher Faculty of Pharmacy & Pharmaceutical Sciences en_US
dc.subject Anti-quorum sensing en_US
dc.subject Pseudomonas aeruginosa en_US
dc.subject biofilm en_US
dc.title Evaluation of three plant extracts against biofilm formation and expression of quorum sensing regulated virulence factors in Pseudomonas aeruginosa en_US
dc.type Article en_US


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