PASTIC Dspace Repository

Studies on self-nanoemulsifying drug delivery system of flurbiprofen employing long, medium and short chain triglycerides

Show simple item record

dc.contributor.author Daar, Junaid
dc.contributor.author Khan, Ahmad
dc.contributor.author Khan, Jallat
dc.contributor.author Khan, Amjad
dc.contributor.author Khan, Gul Majid
dc.date.accessioned 2022-11-03T10:14:29Z
dc.date.available 2022-11-03T10:14:29Z
dc.date.issued 2017-03
dc.identifier.citation Daar, J., Khan, A., Khan, J., Khan, A., & Khan, G. M. (2017). Studies on self-nanoemulsifying drug delivery system of flurbiprofen employing long, medium and short chain triglycerides. Pak. J. Pharm. Sci, 30(2), 601-606. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13922
dc.description.abstract The aim of the study was to successfully design, formulate and evaluate self-nanoemulsifying drug delivery system (SNEDDS) of poorly aqueous soluble drug viz. flurbiprofen using long (LCT), medium (MCT) and short chain triglycerides (SCT). The SNEDDS are thermodynamically stable lipid based drug delivery systems which consist of mixture of oil, surfactant and co-surfactant. Upon aqueous dilution, this mixture produces nano-emulsion spontaneously on slight agitation. The excipients intended to be used were screened for their potential to dissolve the drug and to form clear dispersion upon aqueous dilution. Labrafil M 1944 CS, capryol-90 and triacetin were selected as long, medium and short chain triglycerides, respectively, as lipids while tween-80 and polyethylene glycol-400 (PEG-400)/ethanol (3:1 ratio) were selected as surfactant and co-surfactant, respectively. The excipients were studied at every possible combination ratios using pseudo-ternary diagram. The LCT, MCT and SCT-SNEDDS were optimized using thermodynamic studies, percentage transmittance value, viscosity, refractive index (RI), electrical conductivity, globule size analysis and in-vitro drug release studies. The drug release profiles of optimized SNEDDS were then compared with market product at different pH mediums. The LCT-SNEDDS was considered to be superior for enhancement of the drug bioavailability when compared with other SNEDDS formulations and market product. en_US
dc.language.iso en_US en_US
dc.publisher Faculty of Pharmacy & Pharmaceutical Sciences en_US
dc.subject Self-nanoemulsifying drug delivery system en_US
dc.subject Flurbiprofen en_US
dc.subject Triglycerides en_US
dc.subject bioavailability enhancement en_US
dc.title Studies on self-nanoemulsifying drug delivery system of flurbiprofen employing long, medium and short chain triglycerides en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account