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Development of AD like symptoms following co-administration of AlCl3 and D-gal in rats: A neurochemical, biochemical and behavioural study

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dc.contributor.author Liaquat, Laraib
dc.contributor.author Ahmad, Saara
dc.contributor.author Sadir, Sadia
dc.contributor.author Batool, Zehra
dc.contributor.author Khaliq, Saima
dc.contributor.author Tabassum, Saiqa
dc.contributor.author Emad, Shaista
dc.contributor.author Madiha, Syeda
dc.contributor.author Shahzad, Sidrah
dc.contributor.author Haider, Saida
dc.date.accessioned 2022-11-03T10:25:40Z
dc.date.available 2022-11-03T10:25:40Z
dc.date.issued 2017-03
dc.identifier.citation Liaquat, L., Muddasir, S., Batool, Z., Khaliq, S., Tabassum, S., Emad, S., ... & Haider, S. (2017). Development of AD like symptoms following co-administration of AlCl3 and D-gal in rats: a neurochemical, biochemical and behavioural study. Pakistan Journal of Pharmaceutical Sciences, 30(2 (Suppl.)), 647. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13941
dc.description.abstract Alzheimer’s disease (AD) is an age-related neurodegenerative disorder associated with neurochemical and neurobehavioural alterations. Aluminium (Al) is considered as a contributing factor in the etiology of several neurodegenerative disorders like AD. D-galactose (D-gal) is a physiological nutrient but over supply induces some neurochemical and biochemical changes that exacerbate natural aging process. In this study, we aimed to develop AD animal model by co-administration of Al and D-gal in rats. Male albino Wistar rats were intraperitoneally injected with AlCl3 and D-gal at a dose of 150mg/kg and 300mg/kg respectively for one week. After one week rats were subjected to behavioural analysis. After behavioural analysis rats were decapitated to remove their brain. Biochemical and neurochemical analysis were conducted in whole brain. AlCl3+D-gal significantly induced depressive and anxious behaviour in rats. Rats cognitive abilities were also significantly impaired following AlCl3 and D-gal co-administration. AlCl3 +D-gal significantly altered antioxidant enzyme activities and biogenic amine levels in whole brain. A marked increase in brain lipid peroxidation and acetylcholinesterase activity was found in test rats. These findings suggest that co-administration of AlCl3 and D-gal for one week could induce AD like symptoms and may be used to develop AD animal model. en_US
dc.language.iso en_US en_US
dc.publisher Faculty of Pharmacy & Pharmaceutical Sciences en_US
dc.subject Alzheimer’s disease en_US
dc.subject aluminium chloride en_US
dc.subject D-galactose en_US
dc.subject oxidative stress en_US
dc.subject learning and memory en_US
dc.title Development of AD like symptoms following co-administration of AlCl3 and D-gal in rats: A neurochemical, biochemical and behavioural study en_US
dc.type Article en_US


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