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Drug effect of atorvastatin on middle cerebral atherosclerotic stenosis and high resolution NMR diagnosis

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dc.contributor.author Chen, Xingchi
dc.contributor.author Wang, Sainan
dc.contributor.author Lin, Lulu
dc.contributor.author Li, Yu
dc.contributor.author Zhang, Hui
dc.date.accessioned 2022-11-16T07:54:06Z
dc.date.available 2022-11-16T07:54:06Z
dc.date.issued 2018-05-20
dc.identifier.citation Chen, X., Wang, S., Lin, L., Li, Y., & Zhang, H. (2018). Drug effect of atorvastatin on middle cerebral atherosclerotic stenosis and high resolution NMR diagnosis. Pak J Pharm Sci, 31(3), 1169-73. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14021
dc.description.abstract Atherosclerosis (AS) is a chronic inflammatory reaction with the pathological changes in the lipid deposition of arterial intima. The disorder of blood lipid metabolism is the main factor of the occurrence and development of AS, and the inflammatory reaction and autoimmune reaction also run through the development of AS. In this study, we compared the efficacy and safety of atorvastatin, simvastatin, pravastatin and rosuvastatin in the treatment of AS. At the same time, we used high resolution magnetic resonance imaging (MRI) to assess the changes in plaque area in the middle cerebral artery and the patch area before and after drug treatment. After 6 months of treatment, the number of intima-media thickness (IMT), plaque and plaque in each group were significantly lower than that before the same group. The results showed that statin treatment of AS could significantly reduce the level of blood lipids, but rosuvastatin and atorvastatin had better effects on anti inflammation and maintaining plaque stability and the drug safety was good. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Atorvastatin en_US
dc.subject statins drugs en_US
dc.subject anti-inflammatory mechanisms en_US
dc.subject atherosclerotsis en_US
dc.subject high resolution NMR. en_US
dc.title Drug effect of atorvastatin on middle cerebral atherosclerotic stenosis and high resolution NMR diagnosis en_US
dc.type Article en_US


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