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No.5 September, 2017
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Browsing No.5 September, 2017 by Issue Date

Browsing No.5 September, 2017 by Issue Date

Now showing items 1-20 of 41

Enhancement of anti-inflammatory activity of polyphenolic flavonoid rutin by encapsulation

Jantrawut, Pensak; Phongpradist, Rungsinee; Muller, Monika; Viernstein, Helmut (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2017-09-01)

The cellular mechanisms underlying the anti-inflammatory activity of rutin which has been found to have in vivo inhibitory effects merit more evaluation. The effects of rutin and encapsulated-rutin on lipopolysaccharide ...
Stability comparison of two dermal emulsions containing Hippophae Rhamnoides L. oil

Hussain, Hina; Irfan Masood, Muhammad; Naeem Amir, Muhammad; Majeed Khan, Humaira (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2017-09-02)

Two formulations of multiple emulsion (ME-1 & ME-2) containing Hipophae rhamnoides L. oil were prepared. Along with emulsifiers (Abil EM 90, Synperonic F127), Magnesium and Zinc were used as stabilizer in ME-1 and ME-2 ...
Antimicrobial and wound healing potential of Marham-e-Aatshak (A Herb-o-Mineral formulation)

Anwar, Noman; YT, Kamal; Aftab Ahmad, Mohd; Salam, Shahana; Asif, Mohd; Akhtar, Mohd; Ahmad, Sayeed (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2017-09-03)

Marham-e-Aatshak (MA) is a Unani ointment, with wide use for treating chronic and infectious wounds since long time. This study was designed to screen the antimicrobial and wound healing potential of MA to validate the ...
Role of GAD peptides p217 and p290 in the repair of INS receptor in salivary tissues of type 1 diabetic mice

Eduardo da Silva, Rodrigo; Eduardo da Silva, Rodrigo; Lopes Pinto2, Antonio; da Cunha, Rodrigues; Rojas, Fernanda; Antonio Peroni, Luis; Machado Augusto, Taize; Marchi, Evaldo; Ali Khan, Barkat; José Caldeira, Eduardo (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2017-09-04)

: Glutamate decarboxylase or glutamic acid decarboxylase (GAD) is a protein associated with autoimmune diseases, including type-1 diabetes. This disease is primarily associated with the occurrence of a specific isoform: ...
Hepatoprotective activity and phenolic profile of Zanthoxylum alatum Roxb. fruit extract

Mubashar Sabir, Syed; Batista Texeira Rocha, Joao; Agusti Boligon, Aline; Linde Athayde, Margareth (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2017-09-05)

Zanthoxylum alatum Roxb. (Rutaceae) is a medicinal plant, which abundantly grows in the hilly areas of Pakistan. In the present study, the hepatoprotective activity of the Z. alatum whole fruit was evaluated. The hepat ...
Development and evaluation of novel antihypertensive orodispersible tablets

Ullah Khan, Hafeez; Hanif, Muhammad; M Sarfraz, Rai; Maheen, Safirah; Afzal, Samina; Sher, Mohd; Afza, Khurram; Mahmood, Asif; Shamim, Ayesha (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2017-09-06)

Objective of present study was to enhance patient compliance in pediatrics and geriatrics patients of Hypertension. To achieve this target, innovative orodispersible tablets of atenolol and atorvastatin was developed to ...
Protective effects of traditional Uighur medicine-seeds of Nigella glandulifera Freyn extracts against ccl4-induced acute hepatic injury in mice

Maimaitiyiming, Dilinuer; Kamilijiang, Mayila; Xiaerfuding, Xiadiya; Wen Hui, Shi; Abudureyimu, Meiliwan; Hajinisha, Hajinisha; Aikemu, Ainiwaer (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2017-09-07)

To explore the protective effects of Traditional Uighur medicine Seeds of Nigella glandulifera Freyn (SNF) extracts against CCl4-induced acute hepatic injury in mice. Hepatic injury mice models induced by intraperitoneal ...
Synthesis, antinociceptive activity and structure activity relationship of flavone derivatives

Shoaib, Mohammad; Wadood Ali Shah, Syed; Ali, Niaz; Shah, smail; Shafiullah, Shafiullah; Ayaz, Muhammad; Ayaz, Muhammad; Akhtar, Sohail; Tahir Ayub, Muhammad; Ayaz, Muhammad; Nawaz Tahir, Muhammad; Akhtar, Sohail; Tahir Ayub, Muhammad (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2017-09-08)

Flavonoids are phenolic compounds that have always attracted pharmaceutical researchers and food manufacturers. Nature has indirectly provided us flavones in our daily diet i.e. tea, fruits, juices and vegetables. Flavones ...
Fractionation of crude extracts from controlled dried and commercially available stem bark of Juglans regia and their antimicrobial effects

Jehan Bakht; Sobia Khan; Mohammad Shafi; Arshad Iqbal (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2017-09-09)

The current research investigates the anti-microbial activities of methanol, ethyl acetate, n-hexane , n-butanol and water extracted samples from controlled dried and commercial bark of walnut (Juglans regia) against five ...
To estimate effective antiamyloidogenic property of melatonin and fisetin and their actions to destabilize amyloid fibrils

Hossein Aarabi, Mohammad; Mehdi Mirhashemi, Seyyed (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2017-09-10)

Aggregating of amylin as pancreatic deposition is connected with pancreas degeneration in type 2 diabetes mellitus. Suppression of the amylin accumulation and so instability of the pre-formed pancreatic β-amyloid, may be ...
Histopathological and biochemical assessment of kidney damage in albino wistar rats treated with cytotoxic platinum compounds in combination with 5-FU

Bano, Nusrat; Ikram, Rahila (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2017-09-11)

Kidney cells damage and subsequent renal adverse effects with oxaliplatin are less reported phenomena, whereas cisplatin (CDDP, first generation platinum compound) has therapeutic limitations due to renal toxicity. This ...
Development and validation of HPLC method for the determination of Cefpodoxime Proxetil in human plasma

Bashir, Lubna; Harris Shoaib, Muhammad; Israr, Fozia; Siddiqui, Fahad (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2017-09-12)

A new, simple, accurate, precise and specific method has been developed for the analysis of Cefpodoxime Proxetil in human plasma. The proposed method was developed and validated with the aim to be used in Bioavailabili ...
Changes in blood pressure, vascular reactivity and inflammatory biomarkers following consumption of heated corn oil

Das, Srijit; Afiq Hamsi, Mohamed; Kamisah, Yusof; Mohd Saad Qodriyah, Hj; Othman, Faizah; Emran, Adel; Zakaria, Zaiton; Jaarin, Kamsiah (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2017-09-13)

Consumption of corn oil for cooking purpose is gaining popularity. The present study examined the effect of heated corn oil on blood pressure and its possible mechanism in experimental rats. Thirty male Sprague-Dawley ...
Synthesis of secondary metabolites by Cladosporium resinae (NRL6437) under different growth media and chemical inducers and their pharmaceutical activity

Ali Khan, Abid; Bacha, Nafees; Ahmad, Bashir; Bakht, Jehan; Lutfullah, Ghosia; Ali, Johar (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2017-09-14)

The role of different growth media and chemical enhancer on synthesis of secondary metabolites Cladosporium resinae (NRL-6437) was investigated for their in vitro biological activities. Cladosporium resinae (NRL6437) were ...
Evaluation of antioxidant activity of leaves and fruits extracts of five medicinal plants

Fatima, Iram; Hussain, Tanveer; Rafay, Muhammad; Akram, Muhammad; Bano, Sabahat; Shabbir, Sammia (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2017-09-15)

Antioxidants acts as a defense mechanism that protects against oxidative damage caused by free radicals produced in the body. Medicinal plants are preferably used for various diseases in many countries. The studies were ...
The combination of crocin with cisplatin suppresses growth of gastric carcinoma cell line BGC-823 and promotes cell apoptosis

Luo, Yushuang; Cui, Sen; Tang, Feng; Shen, Cunfang; Qi, Yujuan; Lu, Dianxiang; Ma, Lan; Yang, Yingzhong; Li, Yan; Chen, Rong; Ri-li, GE (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2017-09-16)

This study aimed to investigate the efficacy of crocin alone and in combination with cisplatin in the therapy of gastric carcinoma cells. In this study, human gastric carcinoma cell line BGC-823 was purchased and maintained ...
A stable hydrocortisone nanosuspension for improved dissolution: Preparation, characterization and in vitro evaluation

SM Ali, Hany; Khan, Shahzeb; York, Peter; Shah, Mukarram; Khan, Jahangir; Hussain, Zahid; Ali Khan, Barkat (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2017-09-17)

Drug nanosuspensions have gained tremendous attraction as a platform in drug delivery. In the present work, a nanosuspension was prepared by a wet milling approach in order to increase saturation solubility and dissolution ...
HPLC method development and validation for the determination of Cefaclor in human plasma

Naz, Shazia; Harris Shoaib, Muhammad; Bashir, Lubna; Yousuf, Ismail; Anjum, Fakhsheena; Siddiqui, Fahad; Yaseen, Saima (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2017-09-18)

Cefaclor was analyzed in the human plasma by developing a simple, precise and accurate assay method which was then validated for its accuracy, specificity and precision. The mobile phase comprised of a mixture of sodium ...
Effects of telmisartan on paroxysmal atrial fibrillation in hypertensive patients

Li, Jing; Chen, Hangxiang; Zhou, Qi; Hu, Liangkun; Ma, Li; Han, Hongyan; Li, Wei; Du, Rong; Tian, Li (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2017-09-19)

This study examined the effects and mechanisms of telmisartan in hypertensive patients with paroxysmal atrial fibrillation (PAF). Hypertensive patients with PAF (n=120) were randomized into test (telmisartan) and control ...
Analgesic activities of crude ethanolic extract and various fractions of Adansonia digitata L. grown at the sindh province of Pakistan

Mumtaz, Tayyaba; Rizwani, Ghazala H; Shareef, Huma (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2017-09-20)

The current study aimed to evaluate the analgesic effects of crude extract and fractions of leaves of Adansonia digitata L. (Malvaceae). Fresh leaves were collected, dried under shade and then powdered. Moreover, powder ...

Now showing items 1-20 of 41

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