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Effect of metformin combined with chemotherapeutic agents on gastric cancer cell line AGS

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dc.contributor.author Wu, Xiaochang
dc.date.accessioned 2022-11-17T07:06:07Z
dc.date.available 2022-11-17T07:06:07Z
dc.date.issued 2017-09-20
dc.identifier.citation Wu, X. (2017). Effect of metformin combined with chemotherapeutic agents on gastric cancer cell line AGS. Pakistan journal of pharmaceutical sciences, 30. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14042
dc.description.abstract To explore the effect of metformin combined with chemotherapeutic agents on gastric cancer cell line AGS, 24 patients with gastric cancer were tracked for treatment. CCK-8, Transwell model and flow cytometry were used to detect the cell proliferation, migration ability and other indexes. The metformin inhibited the AGS cell proliferation in a dose- and time-dependent manner (P<0.05). The application of metformin, cisplatin, adriamycin or paclitaxel alone could effectively lower the migration and invasion ability of AGS cells. The metformin in combination with the three chemotherapeutic agents could effectively promote the apoptosis of AGS cells. The metformin in combination with chemotherapeutic agents can effectively and apparently treat the patients with gastric cancer, more significantly in clinic compared to the traditional administration mode. It can effectively promote the apoptosis of AGS cells, thus, it’s worth adopting in clinic. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Metformin en_US
dc.subject chemotherapeutic agents en_US
dc.subject human gastric cancer cell line AGS en_US
dc.subject clinical study en_US
dc.title Effect of metformin combined with chemotherapeutic agents on gastric cancer cell line AGS en_US
dc.type Article en_US


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