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Caveolin-1 in multi drug resistance and two-field lymphadenectomy for thoracic esophageal squamous cell carcinoma

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dc.contributor.author Fang, Weimin
dc.contributor.author Ruan, Weizhong
dc.contributor.author Lin, Shaofeng
dc.contributor.author Chen, Yuanmei
dc.contributor.author Zhu, Kunshou
dc.date.accessioned 2022-11-17T09:27:24Z
dc.date.available 2022-11-17T09:27:24Z
dc.date.issued 2017-09-20
dc.identifier.citation Fang, W., Ruan, W., Lin, S., Chen, Y., & Zhu, K. (2017). Caveolin-1 in multi drug resistance and two-field lymphadenectomy for thoracic esophageal squamous cell carcinoma. Pakistan Journal of Pharmaceutical Sciences, 30. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14046
dc.description.abstract Caveolin-1 plays a very important role in the process of tumor cell transformation. In this paper, we studied the relationship between Cav-1 and other multi drug resistance associated proteins. Moreover, the author compares outcomes according to the extent of lymphadenectomy in patients with upper and middle thoracic esophageal squamous cell carcinoma without clinical cervical metastasis. The short-term and long-term data of 842 consecutive patients who underwent esophagectomy with two-field lymphadenectomy (2FL) or three-field lymphadenectomy (3FL) between February 2005 and July 2013 were retrospectively reviewed. If postoperative infection occurred, according to susceptibility test results, patients were given sensitive antibiotics. The yield of lymph nodes harvested was higher in the 3FL group than in 2FL (P =0.000). There was less blood loss (P =0.000), shorter operative time (P =0.000) less postoperative analgesia needed (P =0.000) and earlier hospital discharge (P =0.000) in 2FL than in 3FL.Overall morbidity was similar in the two groups. However, the rate of major complications was higher after 3FL versus 2FL (P =0.015). There was no 30-day mortality in 2FL and 3FL. The 5-year survival (2FL 35% vs 3FL 38%; P =0.297) and disease-free 5-year survival (2FL 26% vs 3FL 21%; P =0.106) were comparable between the two groups. In univariate analyses, extent of lymphadenectomy was not related to overall 5-year survival. Current results indicated that 2FL may be the preferred lymphadenectomy for upper and middle thoracic esophageal squamous cell carcinoma without clinical cervical metastasis. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Esophageal carcinoma en_US
dc.subject multidrug resistance en_US
dc.subject two-field lymphadenectomy en_US
dc.subject lymphatic metastasis. en_US
dc.title Caveolin-1 in multi drug resistance and two-field lymphadenectomy for thoracic esophageal squamous cell carcinoma en_US
dc.type Article en_US


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