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Enhancement of anti-inflammatory activity of polyphenolic flavonoid rutin by encapsulation

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dc.contributor.author Jantrawut, Pensak
dc.contributor.author Phongpradist, Rungsinee
dc.contributor.author Muller, Monika
dc.contributor.author Viernstein, Helmut
dc.date.accessioned 2022-11-17T10:26:28Z
dc.date.available 2022-11-17T10:26:28Z
dc.date.issued 2017-09-01
dc.identifier.citation Jantrawut, P., Phongpradist, R., Muller, M., & Viernstein, H. (2017). Enhancement of anti-inflammatory activity of polyphenolic flavonoid rutin by encapsulation. Pakistan Journal of Pharmaceutical Sciences, 30(5). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14051
dc.description.abstract The cellular mechanisms underlying the anti-inflammatory activity of rutin which has been found to have in vivo inhibitory effects merit more evaluation. The effects of rutin and encapsulated-rutin on lipopolysaccharide (LPS)- induced IL-6 secretion, NF-κB expression, as well as protein denaturation were investigated. The secretion of IL-6 was not found to have significantly reduced upon incubation with either rutin or encapsulated-rutin at all concentrations. At 100µg/mL, the cells treated with encapsulated-rutin brought about slightly reduced IL-6 secretion but significantly inhibited NF-kB protein expression and protein denaturation in comparison with rutin. Inflammation can be resolved through many mechanisms. The inhibition of IL-6 and NF-kB can serve not only to terminate inflammation but also to inhibit other cytokines or mechanisms. Further investigations are necessary to clarify, verify and establish the antiinflammatory mechanisms of rutin. Additionally, the encapsulation is an interesting technique for enhancing rutin activity. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi en_US
dc.subject Rutin en_US
dc.subject anti-inflammatory activity en_US
dc.subject encapsulation en_US
dc.subject flavonoid en_US
dc.title Enhancement of anti-inflammatory activity of polyphenolic flavonoid rutin by encapsulation en_US
dc.type Article en_US


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