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Development and evaluation of novel antihypertensive orodispersible tablets

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dc.contributor.author Ullah Khan, Hafeez
dc.contributor.author Hanif, Muhammad
dc.contributor.author M Sarfraz, Rai
dc.contributor.author Maheen, Safirah
dc.contributor.author Afzal, Samina
dc.contributor.author Sher, Mohd
dc.contributor.author Afza, Khurram
dc.contributor.author Mahmood, Asif
dc.contributor.author Shamim, Ayesha
dc.date.accessioned 2022-11-18T06:07:10Z
dc.date.available 2022-11-18T06:07:10Z
dc.date.issued 2017-09-06
dc.identifier.citation Khan, H., Sarfraz, R. M., Maheen, S., Mahmood, A., Shamim, A., & Sher, M. (2017). Development and evaluation of novel antihypertensive orodispersible tablets. Pakistan Journal of Pharmaceutical Sciences, 30(5). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14066
dc.description.abstract Objective of present study was to enhance patient compliance in pediatrics and geriatrics patients of Hypertension. To achieve this target, innovative orodispersible tablets of atenolol and atorvastatin was developed to produce instant action by rapidly disintegrating into oral cavity. Three different techniques like direct compression, effervescent and sublimation methods were used to prepare these tablets (Five batches of tablets by each method) by using two superdisintegrants like Sodium starch glycolate and pregelatinized starch alone and in combination. Preformulation studies including rheological analysis (Bulk density, tapped density, Angle of repose, Carr’s compressibility index, Hausner’s ratio), compatibility studies such as Fourier transform infrared spectrophotometry (FTIR) and Differential scanning colorimetry (DSC), Post–compression and stability studies were also performed. Finally, results were statistically evaluated by the applying one way ANOVA test and mean. It was concluded that the formulation F8 containing Sodium starch glycolate 2% and pregelatinized starch 6% found best regarding disintegration time, wetting volume, wetting time, release studies etc. The order in which drug release was quicker is Pregelatinized starch plus Sodium starch glycolate > Pregelatinized starch > Sodium starch glycolate (primojel). It was concluded that sublimation method was the best among three methods used for orodispersible tablets formulations. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi en_US
dc.subject Atenolol en_US
dc.subject atorvastatin en_US
dc.subject orodispersible en_US
dc.subject primojel en_US
dc.subject sublimation en_US
dc.title Development and evaluation of novel antihypertensive orodispersible tablets en_US
dc.type Article en_US


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