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Protective effects of traditional Uighur medicine-seeds of Nigella glandulifera Freyn extracts against ccl4-induced acute hepatic injury in mice

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dc.contributor.author Maimaitiyiming, Dilinuer
dc.contributor.author Kamilijiang, Mayila
dc.contributor.author Xiaerfuding, Xiadiya
dc.contributor.author Wen Hui, Shi
dc.contributor.author Abudureyimu, Meiliwan
dc.contributor.author Hajinisha, Hajinisha
dc.contributor.author Aikemu, Ainiwaer
dc.date.accessioned 2022-11-18T06:15:46Z
dc.date.available 2022-11-18T06:15:46Z
dc.date.issued 2017-09-07
dc.identifier.citation Maimaitiyiming, D., Kamilijiang, M., Xiaerfuding, X., Hui, S. W., Abudureyimu, M., & Aikemu, A. (2017). Protective effects of traditional Uighur medicine-seeds of Nigella glandulifera Freyn extracts against ccl 4-induced acute hepatic injury in mice. Pakistan Journal of Pharmaceutical Sciences, 30(5). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14067
dc.description.abstract To explore the protective effects of Traditional Uighur medicine Seeds of Nigella glandulifera Freyn (SNF) extracts against CCl4-induced acute hepatic injury in mice. Hepatic injury mice models induced by intraperitoneal injection of 0.1% CCl4 olive oil were established. Liver and spleen coefficient, Serum ALT and AST activities, SOD, GSH-Px activities and MDA content in hepatic homogenate were measured and the hepatic histological changes were observed by optical microscope. Serum activities of ALT (P<0.01) and AST (P<0.05) in Alcohol extraction group was decreased; Activity of hepatic homogenate SOD increased in Alcohol extraction group and Water extraction group significantly (P<0.05). Content of MDA was decreased in Alcohol extraction group (P<0.01). Water extracts of SNF have obvious protective effects on hepatic injury induced by CCl4 in mice. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi en_US
dc.subject Traditional Uighur medicine en_US
dc.subject seeds of Nigella glandulifera Freyn en_US
dc.subject carbon tetrachloride (CCl) en_US
dc.subject acute liver injury en_US
dc.title Protective effects of traditional Uighur medicine-seeds of Nigella glandulifera Freyn extracts against ccl4-induced acute hepatic injury in mice en_US
dc.type Article en_US


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