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Synthesis, antinociceptive activity and structure activity relationship of flavone derivatives

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dc.contributor.author Shoaib, Mohammad
dc.contributor.author Wadood Ali Shah, Syed
dc.contributor.author Ali, Niaz
dc.contributor.author Shah, smail
dc.contributor.author Shafiullah, Shafiullah
dc.contributor.author Ayaz, Muhammad
dc.contributor.author Ayaz, Muhammad
dc.contributor.author Akhtar, Sohail
dc.contributor.author Tahir Ayub, Muhammad
dc.contributor.author Ayaz, Muhammad
dc.contributor.author Nawaz Tahir, Muhammad
dc.contributor.author Akhtar, Sohail
dc.contributor.author Tahir Ayub, Muhammad
dc.date.accessioned 2022-11-18T06:33:54Z
dc.date.available 2022-11-18T06:33:54Z
dc.date.issued 2017-09-08
dc.identifier.citation Shoaib, M., Shah, S. W. A., Ali, N., Shah, I., Ayaz, M., Tahir, M. N., ... & Ayub, M. T. (2017). Synthesis, antinociceptive activity and structure activity relationship of flavone derivatives. Pakistan Journal of Pharmaceutical Sciences, 30(5). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14068
dc.description.abstract Flavonoids are phenolic compounds that have always attracted pharmaceutical researchers and food manufacturers. Nature has indirectly provided us flavones in our daily diet i.e. tea, fruits, juices and vegetables. Flavones have got special position in research field of natural and synthetic organic chemistry due to their biological capabilities. Flavone derivative has been synthesized in good yield from ketone and corresponding aldehydes. The structures have been established by different spectroscopic techniques like 1H NMR, 13C NMR, IR and elemental analysis. The compounds were then screened for its acute toxicity and antinociceptive response in mice models with writhings induced by acetic acid, tail immersion and formalin-induced nociception assay procedures and structure activity relationship was established. The compounds were safe up to a maximum dose of 1200 mg/kg body weight in mice. The effects following pretreatment with naloxone were also studied to reveal the involvement of opioid receptors in the antinociceptive action. The flavone derivatives showed significant reduction in number of abdominal constrictions, increase in paw licking response time in both phases and a significant raise in latency time in nociception models. Moreover, the ntinociceptive response was significantly attenuated by pretreatment with naloxone suggesting the nvolvement of opioid system in the antinociceptive action. The promising effects were shown by halogenated flavone. The flavone derivatives showed analgesic response in all models of nociception suggesting the involvement of opioid system in the antinociceptive action. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi en_US
dc.subject Flavone derivatives en_US
dc.subject antinociceptive en_US
dc.subject naloxone en_US
dc.subject opioid en_US
dc.subject structure activity relationship en_US
dc.title Synthesis, antinociceptive activity and structure activity relationship of flavone derivatives en_US
dc.type Article en_US


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