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To estimate effective antiamyloidogenic property of melatonin and fisetin and their actions to destabilize amyloid fibrils

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dc.contributor.author Hossein Aarabi, Mohammad
dc.contributor.author Mehdi Mirhashemi, Seyyed
dc.date.accessioned 2022-11-18T06:49:51Z
dc.date.available 2022-11-18T06:49:51Z
dc.date.issued 2017-09-10
dc.identifier.citation Aarabi, M. H., & Mirhashemi, S. M. (2017). To estimate effective antiamyloidogenic property of melatonin and fisetin and their actions to destabilize amyloid fibrils. Pak J Pharm Sci, 30(5), 1589-1593. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14070
dc.description.abstract Aggregating of amylin as pancreatic deposition is connected with pancreas degeneration in type 2 diabetes mellitus. Suppression of the amylin accumulation and so instability of the pre-formed pancreatic β-amyloid, may be attractive curative goal for mediation of diabetes mellitus. Fluorimetric assay by Thioflavin-T was utilized for investigating the properties of melatonin and fisetin on the generation and instability of β-amyloid near to physiological conditions. The results showed that after 168 hours incubation by shaker incubator in 37o C, melatonin at 10µM and 40 µM repressed amylin amyloid formation by 20.1% and 27.5% respectively (p<0.05) and the similar values of fisetin inhibited the formation of β-sheet structure by 16.5% and 23.2% respectively (p<0.05).The obtained data also confirmed that amyloidal sheet opening was induced by elatonin and fisetin significantly (p<0.05). It may be concluded that islet amyloid cytotoxicity to β-cells may be reduced by melatonin and fisetin, and they should be important constituents of new drugs for diabetes mellitus reatment. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi en_US
dc.subject Amylin en_US
dc.subject Diabetes Mellitus en_US
dc.subject Melatonin en_US
dc.subject Fisetin en_US
dc.subject Amylin fibrils en_US
dc.title To estimate effective antiamyloidogenic property of melatonin and fisetin and their actions to destabilize amyloid fibrils en_US
dc.type Article en_US


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