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Analgesic activities of crude ethanolic extract and various fractions of Adansonia digitata L. grown at the sindh province of Pakistan

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dc.contributor.author Mumtaz, Tayyaba
dc.contributor.author Rizwani, Ghazala H
dc.contributor.author Shareef, Huma
dc.date.accessioned 2022-11-18T10:03:14Z
dc.date.available 2022-11-18T10:03:14Z
dc.date.issued 2017-09-20
dc.identifier.citation Mumtaz, T., Rizwani, G. H., & Shareef, H. (2017). Analgesic activities of crude ethanolic extract and various fractions of Adansonia digitata L. grown at the sindh province of Pakistan. Pakistan Journal of pharmaceutical sciences, 30(5). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14085
dc.description.abstract The current study aimed to evaluate the analgesic effects of crude extract and fractions of leaves of Adansonia digitata L. (Malvaceae). Fresh leaves were collected, dried under shade and then powdered. Moreover, powder was usedto extract with Ethanol and concentrated under reduced pressure, followed by partitioning with organic solvents i.e. Hexane, Ethylacetate, Butanol and Aqueous. These fractions were analyzed for analgesic effect at dose of 50, 100, 200; mg/kg body weight by acetic acid induced writhing, tail flick and hot plate analgesic models. No acute oral toxicity was observed and extracts considered being saved at a dose of 50-3000 mg/kg body weight. Orally administered extract of A. digitata showed analgesic activity described by decrease in writhes counts which was contrast to control. Significant (P<0.05-0.001) increased in latency period in hot plate analgesic test when compared Diclofenac sodium (50 mg/kg) which is used as a standard drug. Furthermore, in tail flick test a dose of (50, 100, 200mg/kg body weight) of extracts exhibited significant (P<0.05-0.001) analgesia which is dose dependent when compared to control group. These findings of analgesic testing have revealed that leaves extract of this nutritional plants possess remarkable antinociceptive effect. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi en_US
dc.subject Adansonia digitata L en_US
dc.subject Malvaceae en_US
dc.subject tail flick test en_US
dc.subject hot plate test en_US
dc.subject antinociceptive activity en_US
dc.title Analgesic activities of crude ethanolic extract and various fractions of Adansonia digitata L. grown at the sindh province of Pakistan en_US
dc.type Article en_US


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