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Moxifloxacin reduces Stenotrophomonas maltophilia adhesion to mouse intestinal tract in vitro

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dc.contributor.author Khadem Zgair, Ayaid
dc.contributor.author A Ghafil, Jenan
dc.contributor.author M. Radif, Hala
dc.contributor.author Naser Radhi, Shamim
dc.contributor.author H Hafiz, Mohammad
dc.contributor.author Fadhel Abbas Albaayit, Shaymaa
dc.date.accessioned 2022-11-23T07:58:25Z
dc.date.available 2022-11-23T07:58:25Z
dc.date.issued 2017-10-03
dc.identifier.citation Zgair, A. K., Ghafil, J. A., Radif, H. M., Radhi, S. N., Hafiz, M. H., & Albaayit, S. F. A. (2017). Moxifloxacin reduces Stenotrophomonas maltophilia adhesion to mouse intestinal tract in vitro. Pakistan Journal of Pharmaceutical Sciences, 30(5). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14097
dc.description.abstract Stenotrophomonas maltophilia is an important opportunistic pathogen that affects immunocompromised individuals. Viable bacterial count method was used to count the number of adhered bacteria. The current study showed the efficiency of S. maltophilia (Sm2) adhesion on different parts of mouse intestinal tract (IT), small intestinal tract (SIT), large intestinal tract (LIT) and rectum (P<0.05) and this ability was equal for each part of IT [ANOVA test (P > 0.05)]. Moxifloxacin (0.03 x MIC) resulted a significant decrease in adhesion of S. maltophilia to SIT (P<0.05) versus control and other sub-inhibitory moxifloxacin concentrations (0.06 x and 1.2 x MIC). It can be concluded from the current study that the S. maltophilia (Sm2) has a good ability to adhere to mouse IT and the lowest concentrations of moxifloxacin (0.03 x MIC) reduced the ability of this bacterium to infect IT by reducing the ability of this bacterium to adhere to IT. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi en_US
dc.subject Intestinal tract en_US
dc.subject mouse en_US
dc.subject Stenotrophomonas maltophilia en_US
dc.subject moxifloxacin en_US
dc.subject adhesion inhibition en_US
dc.title Moxifloxacin reduces Stenotrophomonas maltophilia adhesion to mouse intestinal tract in vitro en_US
dc.type Article en_US


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