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Urease inhibitory activity of Hippophae rhamnoids and Cassia fistula

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dc.contributor.author Ali Khan, Barkat
dc.contributor.author Akhtar, Naveed
dc.contributor.author Khan, Haroon
dc.contributor.author Mustafa, Ghulam
dc.contributor.author Rasul Niazi, Zahid
dc.contributor.author Menaa, Farid
dc.date.accessioned 2022-11-28T04:42:25Z
dc.date.available 2022-11-28T04:42:25Z
dc.date.issued 2017-10-04
dc.identifier.citation Khan, B. A., Akhtar, N., Khan, H., Mustafa, G., Niazi, Z. R., & Menna, F. (2017). Urease inhibitory activity of Hippophae rhamnoids and Cassia fistula. Pakistan Journal of Pharmaceutical Sciences, 30(5), 1779-1781. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14101
dc.description.abstract The rational use of plants as medicine is traced back over five epochs to ancient documents of early civilizations and is certainly as old as mankind. These medicines originally developed from crude drugs like tinctures and tinctures. Minimum 119 chemical substances are derived from 90 plant species and used all over the world as medicines, several of them containing compounds derived from or modelled after naturally occurring lead molecules and 74% of these derived from orthodox medicinal plants. 252 drugs (11%) are believed to be basic and essential by the WHO and are exclusively of plant origin. We have examined anti-urease activity of ethyl alcohol (Et-OH) and methyl alcohol (Me-OH) extracts of H. rhamnoides and Cassia fistula. Berthelot assay was used for the determination of antiurease activity. The enzyme activity and inhibition was measured through catalytic effects of urease on urea by measuring change in absorbance in the absence and in the presence of inhibitor at 625nm using UV spectrophotometer. In the study, both Et-OH and Me-OH extracts of H. rhamnoides (91.69%±1.21) and C. fisstula (79.44%±0.55) showed stronger action against urease activity. An overview on the medicinal uses of H. rhamnoides and C. fisstula showing anti-urease activity may predict their possible alternative use for stomach problems. This study may help to explain the beneficial effects of these plants against stomach infection associated with pathogenic strains of H. pylori as Urease is the most prominent protein component of H. pylori. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject H. pylori en_US
dc.subject Ulcer en_US
dc.subject Urease en_US
dc.title Urease inhibitory activity of Hippophae rhamnoids and Cassia fistula en_US
dc.type Article en_US


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