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Colonization rates and immune status of children against Streptococcus pneumoniae before the introduction of pneumococcal conjugate vaccine

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dc.contributor.author Bibi, Safia
dc.contributor.author Ruba Siddiqui, Taranum
dc.contributor.author Furqan Hassan, Syed
dc.contributor.author Ahmed, Waquaruddin
dc.date.accessioned 2022-11-28T04:49:34Z
dc.date.available 2022-11-28T04:49:34Z
dc.date.issued 2017-10-06
dc.identifier.citation Bibi, S., Siddiqui, T. R., Hassan, S. F., & Ahmed, W. (2017). Colonization rates and immune status of children against Streptococcus pneumoniae before the introduction of pneumococcal conjugate vaccine. Pakistan Journal of Pharmaceutical Sciences, 30(5), 1791-1797. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14103
dc.description.abstract Pneumococcal infections contribute to high morbidity and mortality in Pakistan. Pneumococcal colonization rates and immune status of children before and after vaccination can serve as an important indicator to determine the success of immunization program. Aim of this study was to determine the pneumococcal colonization rate and immune status of children (<3-years) before the introduction of Pneumococcal immunization in EPI program. A cross sectional study of 3-months duration was conducted in collaboration with EPI Centre of NICH, Karachi. A total of 192 healthy children aged 3-months to 3-years were included in the study. Children with chronic or recurrent pulmonary disease were excluded. Demographic data and presence of any risks for pneumococcal colonization or immunity was recorded. Nasopharyngeal swabs were collected to determine the presence of S. pneumoniae and sensitivity pattern of the isolates. Blood samples were collected to determine immune status of these children. Sixty (31%) children were found to carry S. pneumoniae in their nasopharynx. Resistance to cotrimoxazole, erythromycin, chloramphenicol, penicillin and vancomycin was 100%, 30%, 25%, 22% and 0% respectively. Mean anti-PCP titre of children was 23.3mg/L. Mean antiPCP titre in children who had previously suffered from RTI was significantly increased (p-value 0.039). This study may serve as baseline report for evaluating the success of pneumococcal immunization in future. A significant drop in nasopharyngeal colonization rates post vaccination would depict the success of pneumococcal immunization. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Pneumococcal conjugate vaccine en_US
dc.subject Pneumococcal colonization en_US
dc.subject antibiotics sensitivity en_US
dc.subject vaccine en_US
dc.title Colonization rates and immune status of children against Streptococcus pneumoniae before the introduction of pneumococcal conjugate vaccine en_US
dc.type Article en_US


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