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Antidiabetic effects of native date fruit Aseel (Phoenix dactylifera L.) in normal and hyperglycemic rats

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dc.contributor.author Ahmed, Shadab
dc.contributor.author Alam Khan, Rafeeq
dc.contributor.author Jamil, Subia
dc.contributor.author Afroz, Syeda
dc.date.accessioned 2022-11-28T04:52:50Z
dc.date.available 2022-11-28T04:52:50Z
dc.date.issued 2017-10-07
dc.identifier.citation Ahmed, S., Khan, R. A., Jamil, S., & Afroz, S. (2017). Antidiabetic effects of native date fruit Aseel (Phoenix dactylifera L.) in normal and hyperglycemic rats. Pakistan journal of pharmaceutical sciences, 30(5). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14104
dc.description.abstract Change in dietary pattern, sedentary life style and increasing stresses are contributing factors for high prevalence of diabetes mellitus. Diabetic complications often lead to cardiovascular diseases, hypertension and hyperlipidemia that are the leading cause death and disability all over the world. Apart from pharmacotherapy, use of antihyperglycemic medicinal food is a new aspect in diabetes management and prevention of its complications. Phoenix dactylifera (date palm) has been traditionally used for different diseases because of the presence of bioactive agents like anthocyanin, phenols, sterols, carotenoids, procyanidins and flavonoids however its potential as a medicinal food is still unclear. Native date fruit variety Aseel oral suspension was evaluated using 32 normoglycemic and hyperglycemic Sprague dawley rats with two doses (300 and 600mg/kg) against control, disease control and standard drug (Glibenclamide 2.5mg/kg). Outcomes of normoglycemic studies reveals insignificant glucose lowering effects however hyperglycemic studies (glucose challenge and Alloxan inducted hyperglycemia) demonstrates significant glucose lowering effect of Aseel date especially with 300mg/kg dose. Data obtained during this study reveal significant antihyperglycemic effects of Aseel dates in diabetes management however further preclinical and clinical studies are required to verify the same. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject diabetes mellitus en_US
dc.subject Phoenix dactylifera (Aseel) en_US
dc.subject normoglycemic en_US
dc.subject hyperglycemic en_US
dc.subject Alloxan en_US
dc.title Antidiabetic effects of native date fruit Aseel (Phoenix dactylifera L.) in normal and hyperglycemic rats en_US
dc.type Article en_US


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