Volume 22: Recent submissions

  • ANTINOCICEPTIVE AND ANTI-PYRETIC ACTIVITY OF BENINCASA HISPIDA (THUNB.) COGN. IN WISTAR ALBINO RATS 
    LATIEF QADRIE, ZULFKAR; TAYEB HAWISA, NAJAT; WAJID ALI KHAN, MOHD.; SAMUEL, MOSES; ANANDAN, R (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-07-10)
    The seeds of Benincasa hispida (Thunb) COGN. (Family: Cucurbitaceae) was extracted with ethanol and was used to study acute toxicity, antinociceptive and anti-pyretic effects. Brewer’s yeast (15%) was used to induce pyrexia ...
  • EVALUATION OF ANTIBACTERIAL ACTIVITY, PHENOL AND FLAVONOID CONTENTS OF THESPESIA POPULNEA FLOWER EXTRACTS 
    SARAVANAKUMAR, A; VENKATESHWARAN, K; VANITHA, J; GANESH, M; VASUDEVAN, M; SIVAKUMAR, T (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-07-08)
    Flavonoids which were reported as having many pharmacological activities, antimicrobial, antioxidant, cytotoxic, chemoprevention activities and they possess strong antiproliferative effects related to inhibition of cell ...
  • ANTIOXIDANT ACTIVITY, PHENOL AND FLAVONOID CONTENTS OF 13 CITRUS SPECIES PEELS AND TISSUES 
    GHASEMI, KAMRAN; GHASEMI, YOSEF; ALI EBRAHIMZADEH, MOHAMMAD (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-07-07)
    Methanolic extracts of 13 commercially available citrus spp., peels and tissues growing in Iran were investigated for their antioxidant activity by DPPH method. IC50 for antioxidant activity ranged from 0.6-3.8 mg ml-1. ...
  • EFFECT OF AQUEOUS EXTRACTS OF ALLIGATOR PEAR SEED (PERSEA AMERICANA MILL) ON BLOOD GLUCOSE AND HISTOPATHOLOGY OF PANCREAS IN ALLOXAN-INDUCED DIABETIC RATS 
    EDEM, DO; EKANEM, IS; EBONG, PE (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-07-06)
    Effects of aqueous extract of alligator pear seed on normal and alloxan-induced diabetic rats were investigated in 6 groups of rats (5 rats per group). Test groups were made diabetic with intra-peritoneal injection of ...
  • COMPARISON OF HYPOTENSIVE AND HYPOLIPIDEMIC EFFECTS OF CATHARANTHUS ROSEUS LEAVES EXTRACT WITH ATENOLOL ON ADRENALINE INDUCED HYPERTENSIVE RATS 
    ARA, NAZNIN; RASHID, MAMUNUR; AMRAN, MD SHAH (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-07-05)
    The leaves extract of Catharanthus roseus was investigated for hypotensive and hypolipidemic effects in adrenaline-induced hypertensive rats (AIHR) and compared with those of Atenolol in a crossover design. The pharmacologically ...
  • QUANTITATION OF ALFUZOSIN HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS BY RP-HPLC 
    GANESH, MANI; UPPATYAY, SATISH; TIVARI, RISHI; KAMALAKANNAN, KALIAPPAN; RATHINAVEL, GOVINDASAMY; GANGULLY, SWASTIKA; SIVAKUMAR, THANGAVEL (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-07-04)
    An isocratic reversed phase high-performance liquid chromatographic (HPLC) method with ultraviolet detection at 245 nm has been developed for the determination of alfuzosin hydrochloride in dosage formulation. Good ...
  • DICLOFENAC INHIBITS PROLIFERATION BUT NOT NGF-INDUCED DIFFERENTIATION OF PC12 CELLS 
    RAJABALIAN, SAEED; SHAMSI MEIMANDI, MANZUMEH; BADINLOO, MARZIYEH (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-07-03)
    Diclofenac is a non-steroidal anti-inflammatory drug that is prescribed for treatment of rheumatic diseases and as an analgesic. Although the information about these side effects has been widely reported, little is know ...
  • COMPARATIVE STUDY OF TWO BACTERIOCINS PRODUCED BY REPRESENTATIVE INDIGENOUS SOIL BACTERIA 
    SALEEM, FARAH; AHMAD, SAMIA; YAQOOB, ZOBIA; AJAZ RASOOL, SHEIKH (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-07-02)
    The aim of this research work was to identify and characterized the bacteriocins produced by soil-associated bacteria. Bacillocin from Bacillus brevis Bb and pyocin from Pseudomonas aeruginosa Pa were found bioactive only ...
  • ANTIBACTERIAL ACTIVITY IN VITRO OF THYMUS CAPITATUS FROM JORDAN 
    N QARALLEH, HAITHAM; M ABBOUD, MUAYAD; M KHLEIFAT, KHALED; A TARAWNEH, KHALED; Y ALTHUNIBAT, OSAMA (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-10-01)
    This study was carried out to evaluate the antibacterial activity of aqueous and organic extracts of Thymus capitatus L. (Lamiaceae) leaves and stems. Dried ground powder leaves and stems were extracted with water (aqueous ...
  • RESIDUAL SOLVENT ANALYSIS IN HYDROCHLORIDE SALTS OF ACTIVE PHARMACEUTICAL INGREDIENTS 
    PURANIK, SB PURANIK; PAWAR, R PAWAR; LALITHA, N LALITHA; PAI AND GK RAO, PN SANJAY (Karachi: Faculty of Pharmacy, University of Karachi, 2009-10)
    GMP conditions commands to control adequately the quality of APIs by checking the levels of residual solvents. Organic solvents such as acetone, ethyl acetate, isopropyl alcohol, methanol, tetrahydrofuran and toluene ...
  • ANTIMICROBIAL ACTIVITIES OF THE VOLATILE OILS OF OCIMUM BACILICUM L. AND OCIMUM GRATISSIMUM L. (LAMIACEAE) AGAINST SOME AEROBIC DENTAL ISOLATES 
    AHONKHAI I, AHONKHAI; AYINDE BA, AYINDE; EDOGUN O, EDOGUN; UHUWMANGHO MU, UHUWMANGHO (Karachi: Faculty of Pharmacy, University of Karachi, 2009-10)
    Essential or volatile oils of plants have been variously reported to have many medicinal applications. Their probable uses against oral microbes have received little attention. Oral swabs obtained from eighteen dental ...
  • SOLID DISPERSIONS: A REVIEW 
    K, DHIRENDRA; S, LEWIS; N, UDUPA; K, ATIN (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-20)
    Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of hydrophobic drugs. This article reviews the various preparation techniques ...
  • FREQUENCY OF ASPIRIN RESISTANCE IN PATIENTS WITH CORONORY ARTERY DISEASE IN PAKISTAN 
    AKHTAR, NAVEED; JUNAID, AYESHA; KHALID, AYESHA; AHMED, WAQAS; ALI SHAH, MUMTAZ; UR RAHMAN, HABIB (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-19)
    Aspirin resistance is an emerging clinical entity. However the data available on aspirin resistance in Asian population is scarce. This study was initiated to prospectively evaluate the frequency of aspirin resistance ...
  • QUALITY OF CEFTRIAXONE IN PAKISTAN: REALITY AND RESONANCE 
    ALI, OBAID (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-18)
    The quality of pharmaceuticals is a global concern, counterfeit/ poor quality/ substandard medicines can cause harms in various ways: In a number of developing countries including Pakistan there is reportedly a high incidence ...
  • EFFECT OF HYDROPHILIC NATURAL GUMS IN FORMULATION OF ORAL-CONTROLLED RELEASE MATRIX TABLETS OF PROPRANOLOL HYDROCHLORIDE 
    RAJESH, KS; VENKATARAJU, MP; GOWDA, DV (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-17)
    In order to develop a controlled delivery of highly water-soluble propranolol hydrochloride (PPHCl) using hydrophilic natural gums (xanthan gum [X] and locust bean gum [LBG]) as cost-effective, nontoxic, easily available. ...
  • EXPERIMENTAL DIABETIC NEPHROPATHY CAN BE PREVENTED BY PROPOLIS: EFFECT ON METABOLIC DISTURBANCES AND RENAL OXIDATIVE PARAMETERS 
    M ABO-SALEM, OSAMA; H EL-EDEL, RAWHIA; ELDIN I HARISA, GAMAL; EL-HALAWANY, NERMIN; M GHONAIM, MABROUK (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-16)
    Oxidative stress may play a key role in the pathogenesis of diabetic nephropathy. Propolis and its extract have antioxidant properties. The effect of ethanolic extract of propolis against experimental diabetes mellitus-associated ...
  • BIOEQUIVALENCE STUDIES OF TWO BRANDS OF MELOXICAM TABLETS IN HEALTHY PAKISTANI VOLUNTEERS 
    FARID HASAN, SYED MUHAMMAD; HARRIS SHOAIB, MUHAMMAD; HASSAN, FOUZIA; REHMAN, INAM-UR (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-15)
    The pharmacokinetic parameters of two oral formulations of meloxicam tablets were compared in a randomized, single oral dose; two treatments cross over design in 12 healthy male volunteers belonging to Pakistan under ...
  • ENHANCED TRANSDERMAL DELIVERY OF KETOPROFEN FROM BIOADHESIVE GELS 
    SINGH, S; GAJRA, B; RAWAT, M; MUTHU, M S (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-14)
    The aim of this study was to evaluate and compare the in vitro and in vivo transdermal potential of bioadhesive gels of ketoprofen by using gelling polymers like sodium carboxymethylcellulose, xanthan gum, poloxamer ...
  • INVESTIGATION OF VASOACTIVE ION CONTENT OF HERBS USED IN HEMORRHOID TREATMENT IN TURKEY 
    GULEC, MAHIR; OGUR, RECAI; GUL, HÜSAMETTIN; KORKMAZ, AHMET; BAKIR, BILAL (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-13)
    Objectives: The aim of the present study is to determine anion and cation contents of the herbals used in Turkish folk remedy to explore the rationale of their use in hemorrhoid treatment in the context of the vasoactivity ...
  • BIOLOGICAL SCREENING OF EUPHORBIA HELIOSCOPIA L. 
    UZAIR, M; LOOTHAR, B A; CHOUDHARY, B A (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-12)
    The present research is preliminary biological screening of Euphorbia helioscopia L. (Euphorbiaceae). Dichloromethane and methanol extracts of the aerial parts of the plant were investigated for their antioxidant, antifungal, ...

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