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Browsing Issues by Title

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  • FREQUENCY OF ASPIRIN RESISTANCE IN PATIENTS WITH CORONORY ARTERY DISEASE IN PAKISTAN 
    AKHTAR, NAVEED; JUNAID, AYESHA; KHALID, AYESHA; AHMED, WAQAS; ALI SHAH, MUMTAZ; UR RAHMAN, HABIB (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-19)
    Aspirin resistance is an emerging clinical entity. However the data available on aspirin resistance in Asian population is scarce. This study was initiated to prospectively evaluate the frequency of aspirin resistance ...
  • IN VITRO ANTIMICROBIAL ACTIVITIES OF EXTRACTS OF CARPOLOBIA LUTEA ROOT 
    ETTEBONG, ETTE; NWAFOR, PAUL (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-07-18)
    Several plants are used in folk medicine to treat infections. Carpolobia lutea, G.Don (Polygalaceae) is a medicinal plant commonly used by herbalists in Southern Nigeria against dental and genitourinary infections. The ...
  • IN VITRO ANTIOXIDANT ACTIVITY OF ROOTS OF THESPESIA LAMPAS DALZ AND GIBS 
    SWARAN B, SANGAME; KRISHNAN BR, BALA; DESHRAJ, CHUMBHALE; B, JAYAKAR (Karachi: Faculty of Pharmacy, University of Karachi, 2009-10-04)
    The free radical scavenging potential of roots of Thespesia lampas Dalz and Gibs was studied by different antioxidant models. Free radicals are implicated for more than 80 diseases including Diabetes mellitus, arthritis, ...
  • IN VITRO STUDY ON TAMSULOSIN RELEASE KINETICS FROM BIODEGRADABLE PLGA IN SITU IMPLANTS 
    MD. ELIAS-AL-MAMUN; HUMAIRA AFREEN KHAN; IRIN DEWAN; REZA-UL JALIL (2009-11-02)
    The objective of this study was to evaluate the effect of drug loading and the effect of excipients on the release pattern of tamsulosin tydrochloride from in situ PLGA implants formed in vitro in gelatin gel. This system ...
  • INVESTIGATION OF VASOACTIVE ION CONTENT OF HERBS USED IN HEMORRHOID TREATMENT IN TURKEY 
    GULEC, MAHIR; OGUR, RECAI; GUL, HÜSAMETTIN; KORKMAZ, AHMET; BAKIR, BILAL (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-13)
    Objectives: The aim of the present study is to determine anion and cation contents of the herbals used in Turkish folk remedy to explore the rationale of their use in hemorrhoid treatment in the context of the vasoactivity ...
  • L-ARGININE AUGMENTS THE ANTIOXIDANT EFFECT OF GARLIC AGAINST ACETIC ACID -INDUCED ULCERATIVE COLITIS IN RATS 
    ELDIN I. HARISA, GAMAL; M. ABO-SALEM, OSAMA; M. EL-SAYED, EL-SAYED; I. TAHA, EHAB; EL-HALAWANY5, NERMIN (2009-10)
    Garlic contains many sulfhydryl compounds that act as antioxidants. However, the role of nitric oxide (NO) in inflammation is controversial. The aim of the present study is to investigate the possible protective effect of ...
  • ORAL GLUCOSE TOLERANCE TEST (OGTT) IN NORMAL CONTROL AND GLUCOSE INDUCED HYPERGLYCEMIC RATS WITH COCCINIA CORDIFOLIA L. AND CATHARANTHUS ROSEUS L. 
    ISLAM, MD. ARIFUL; AKHTAR, MOST. AFIA; ISLAM KHAN, MD. RAFIQUL; HOSSAIN, MD. SAROWAR; ALAM, A. H. M. KHURSHID; IMAM IBNE WAHED, MIR; AMRAN, MD. SHAH; MOKADDESUR RAHMAN, BYTUL; AHMED, MARUF (Karachi: Faculty of Pharmacy, University of Karachi, 2009-10)
    The aim of this study is to investigate the hypoglycemic effects of petroleum ether, chloroform and ethyl acetate fractions isolated from ethanolic extracts of Coccinia cordifolia and Catharanthus roseus on normal control ...
  • POTENTIAL ANTIDIABETIC AND HYPOLIPIDEMIC EFFECTS OF PROPOLIS EXTRACT IN STREPTOZOTOCIN-INDUCED DIABETIC RATS 
    M EL-SAYED, EL-SAYED; M ABO-SALEM, OSAMA; A ALY, HAMDY; M MANSOUR, AHMED (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-09)
    Free radicals have been implicated in the pathogenesis of diabetes mellitus leading to various complications including atherosclerosis. Propolis was reported to have oxygen radical scavenging activity. The present study was ...
  • QUALITY OF CEFTRIAXONE IN PAKISTAN: REALITY AND RESONANCE 
    ALI, OBAID (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-18)
    The quality of pharmaceuticals is a global concern, counterfeit/ poor quality/ substandard medicines can cause harms in various ways: In a number of developing countries including Pakistan there is reportedly a high incidence ...
  • QUANTITATION OF ALFUZOSIN HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS BY RP-HPLC 
    GANESH, MANI; UPPATYAY, SATISH; TIVARI, RISHI; KAMALAKANNAN, KALIAPPAN; RATHINAVEL, GOVINDASAMY; GANGULLY, SWASTIKA; SIVAKUMAR, THANGAVEL (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-07-04)
    An isocratic reversed phase high-performance liquid chromatographic (HPLC) method with ultraviolet detection at 245 nm has been developed for the determination of alfuzosin hydrochloride in dosage formulation. Good ...
  • QUANTITATIVE DETERMINATION OF LEVOFLOXACIN HEMIHYDRATE IN BULK AND TABLETS BY UV-SPECTROPHOTOMETRY AND FIRST ORDER DERIVATIVE METHODS 
    AA, SHIRKHEDKAR; SJ, SURANA (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-07-11)
    Two Simple, rapid, accurate and economical ‘UV Spectrophotometry’ and ‘First Order Derivative’ methods have been developed for determination of levofloxacin hemihydrate in bulk and tablets. In (10% v/v) acetonitrile, the ...
  • REPEATED ADMINISTRATION OF NIGELLA SATIVA DECREASES 5-HT TURNOVER AND PRODUCES ANXIOLYTIC EFFECTS IN RATS 
    PERVEEN, TAHIRA; HAIDER, SAIDA; KANWAL, SUMERA; JABEEN HALEEM, ARAKHSHAN (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-07-04)
    The black cumin or Nigella sativa L. seeds have many acclaimed medicinal properties. Pharmacological studies have been conducted on the aqueous and methanol extracts of N. sativa L. seeds to evaluate their effects on the ...
  • RESIDUAL SOLVENT ANALYSIS IN HYDROCHLORIDE SALTS OF ACTIVE PHARMACEUTICAL INGREDIENTS 
    PURANIK, SB PURANIK; PAWAR, R PAWAR; LALITHA, N LALITHA; PAI AND GK RAO, PN SANJAY (Karachi: Faculty of Pharmacy, University of Karachi, 2009-10)
    GMP conditions commands to control adequately the quality of APIs by checking the levels of residual solvents. Organic solvents such as acetone, ethyl acetate, isopropyl alcohol, methanol, tetrahydrofuran and toluene ...
  • THE ROLE OF POMEGRANATE (PUNICA GRANATUM L.) IN COLON CANCER 
    A. KHAN, SEHER (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-07-20)
    Colon cancer is one of the major causes of cancer-related death in the Western world. Although cytotoxic chemotherapeutic agents are available to treat the disease, these agents become ineffective as the disease advances ...
  • SEPARATION OF PHENOLIC GLYCOLIPIDS IN MYCOBACTERIUM BOVIS BCG BY REVERSED-PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY 
    SALIMI, MONA; POURABDI, LADAN; ZAKERI, MARYAM; ABDIPOUR, NAZANIN (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-07-05)
    A crude phenolic glycolipid extract from Mycobacterium bovis BCG was fractionated by column chromatography. A reversed-phase high performance liquid chromatography (HPLC) method with UV detection at 275nm was developed ...
  • SIMULTANEOUS DETERMINATION OF METRONIDAZOLE AND MICONAZOLE NITRATE IN GEL BY HPTLC 
    B. MESHRAM, DHANANJAY; B. BAGADE, SHASHIKANT; R. TAJNE, MADHUKAR (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-07-16)
    A new, simple, precise, rapid and selective high-performance thin-layer chromatographic (HPTLC) method for the simultaneous quantification of Metronidazole (MTZ) and Miconazole nitrate (MCZ) in gel has been developed. ...
  • SOLID DISPERSIONS: A REVIEW 
    K, DHIRENDRA; S, LEWIS; N, UDUPA; K, ATIN (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-20)
    Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of hydrophobic drugs. This article reviews the various preparation techniques ...
  • STUDY OF THE ANTI-INFLAMMATORY AND ANALGESIC EFFECTS OF NOVEL RIGID BENZOFURAN-3, 4-DIHYDROXY CHALCONE BY FORMALIN, HOT-PLATE AND CARRAGEENAN TESTS IN MICE 
    REZA HEIDARI, MAHMOUD; FOROUMADI, ALIREZA; NOROOZI, HOJAT; SAMZADEH-KERMANI, ALI; SARVAR AZIMZADEH, BEHZAD (Karachi: Faculty of Pharmacy, University of Karachi, 2009-10)
    It is reported that dihydroxy chalcones have analgesic and anti-inflammatory effects. Study of the structure activity relationship (SAR) shows that benzofuran-3-one derivatives may be more effective in this respect. In ...
  • SUSTAINED OPHTHALMIC DELIVERY OF OFLOXACIN FROM AN ION-ACTIVATED IN SITU GELLING SYSTEM 
    ABRAHAM, SINDHU; FURTADO, SHARON; S, BHARATH; BV, BASAVARAJ; R, DEVESWARAN; V, MADHAVAN (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-10)
    The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solutions due to rapid pre-corneal elimination of the drug may be overcome by the use of in situ gel forming systems that are instilled as ...
  • THEOPHYLLINE LOADED GASTRORETENTIVE FLOATING TABLETS BASED ON HYDROPHILIC POLYMERS: PREPARATION AND IN VITRO EVALUATION 
    KHAN, FERDOUS; MILLAT IBN RAZZAK, MD. SHAIKHUL; RAHMAN KHAN, MD. ZIAUR; ABUL KALAM AZAD, MOHAMMAD; AHMED CHOWDHURY, JAKIR; REZA, MD. SELIM (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-07)
    This investigation describes the preparation and in vitro evaluation of gastroretentive floating tablet of theophylline. Two hydrophilic cellulose derivatives, Methocel K100M and Methocel K15MCR were evaluated for their ...

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