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Browsing Issues by Issue Date

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  • ZINC DEFICIENCY AND SUPPLEMENTATION IN OVARIECTOMIZED RATS: THEIR EFFECT ON SERUM ESTROGEN AND PROGESTERONE LEVELS AND THEIR RELATION TO CALCIUM AND PHOSPHORUS 
    SUNAR, FUSUN; KERIM KASIM BALTACI, ABDUL; ERGENE, NEYHAN; MOGULKOC, RASIM (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-06)
    The aim of this study is to examine how zinc deficiency or supplementation affects estrogen and progesterone and calcium and phosphorus levels in the serum. The study was carried out on 40 adult female rats of SpraqueDawley ...
  • THEOPHYLLINE LOADED GASTRORETENTIVE FLOATING TABLETS BASED ON HYDROPHILIC POLYMERS: PREPARATION AND IN VITRO EVALUATION 
    KHAN, FERDOUS; MILLAT IBN RAZZAK, MD. SHAIKHUL; RAHMAN KHAN, MD. ZIAUR; ABUL KALAM AZAD, MOHAMMAD; AHMED CHOWDHURY, JAKIR; REZA, MD. SELIM (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-07)
    This investigation describes the preparation and in vitro evaluation of gastroretentive floating tablet of theophylline. Two hydrophilic cellulose derivatives, Methocel K100M and Methocel K15MCR were evaluated for their ...
  • BACTERIOCIN PRODUCTION BY INDIGENOUS MARINE CATFISH ASSOCIATED VIBRIO SPP. 
    SAEED ZAI, ARSALAN; AHMAD, SAMIA; AJAZ RASOOL, SHEIKH (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-08)
    Fifty strains of genus Vibrio were isolated (identified) from healthy and diseased marine catfish(es). The isolates were screened for bacteriocin (vibriocin) production. About 32% isolates were found bacteriocin producers. ...
  • POTENTIAL ANTIDIABETIC AND HYPOLIPIDEMIC EFFECTS OF PROPOLIS EXTRACT IN STREPTOZOTOCIN-INDUCED DIABETIC RATS 
    M EL-SAYED, EL-SAYED; M ABO-SALEM, OSAMA; A ALY, HAMDY; M MANSOUR, AHMED (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-09)
    Free radicals have been implicated in the pathogenesis of diabetes mellitus leading to various complications including atherosclerosis. Propolis was reported to have oxygen radical scavenging activity. The present study was ...
  • SUSTAINED OPHTHALMIC DELIVERY OF OFLOXACIN FROM AN ION-ACTIVATED IN SITU GELLING SYSTEM 
    ABRAHAM, SINDHU; FURTADO, SHARON; S, BHARATH; BV, BASAVARAJ; R, DEVESWARAN; V, MADHAVAN (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-10)
    The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solutions due to rapid pre-corneal elimination of the drug may be overcome by the use of in situ gel forming systems that are instilled as ...
  • AN EXPERIMENTAL DESIGN FOR FINDING OF MINIMUM DOSAGE OF CARBAMAZEPINE AND VALPROATE IN PREVENTING OF SEIZURE ATTACKS 
    SAMAEI, AFSHIN; NOBAHAR, MONIR; A. VAFAEI, ABBAS (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-11)
    Previous studies have shown that physicians use high doses of Carbamazepine (CBZ) and Valproate (VPA) to control of epileptic attacks, while these drugs incur of many side effects include of gastrointestinal, hematologic, ...
  • BIOLOGICAL SCREENING OF EUPHORBIA HELIOSCOPIA L. 
    UZAIR, M; LOOTHAR, B A; CHOUDHARY, B A (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-12)
    The present research is preliminary biological screening of Euphorbia helioscopia L. (Euphorbiaceae). Dichloromethane and methanol extracts of the aerial parts of the plant were investigated for their antioxidant, antifungal, ...
  • INVESTIGATION OF VASOACTIVE ION CONTENT OF HERBS USED IN HEMORRHOID TREATMENT IN TURKEY 
    GULEC, MAHIR; OGUR, RECAI; GUL, HÜSAMETTIN; KORKMAZ, AHMET; BAKIR, BILAL (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-13)
    Objectives: The aim of the present study is to determine anion and cation contents of the herbals used in Turkish folk remedy to explore the rationale of their use in hemorrhoid treatment in the context of the vasoactivity ...
  • ENHANCED TRANSDERMAL DELIVERY OF KETOPROFEN FROM BIOADHESIVE GELS 
    SINGH, S; GAJRA, B; RAWAT, M; MUTHU, M S (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-14)
    The aim of this study was to evaluate and compare the in vitro and in vivo transdermal potential of bioadhesive gels of ketoprofen by using gelling polymers like sodium carboxymethylcellulose, xanthan gum, poloxamer ...
  • BIOEQUIVALENCE STUDIES OF TWO BRANDS OF MELOXICAM TABLETS IN HEALTHY PAKISTANI VOLUNTEERS 
    FARID HASAN, SYED MUHAMMAD; HARRIS SHOAIB, MUHAMMAD; HASSAN, FOUZIA; REHMAN, INAM-UR (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-15)
    The pharmacokinetic parameters of two oral formulations of meloxicam tablets were compared in a randomized, single oral dose; two treatments cross over design in 12 healthy male volunteers belonging to Pakistan under ...
  • EXPERIMENTAL DIABETIC NEPHROPATHY CAN BE PREVENTED BY PROPOLIS: EFFECT ON METABOLIC DISTURBANCES AND RENAL OXIDATIVE PARAMETERS 
    M ABO-SALEM, OSAMA; H EL-EDEL, RAWHIA; ELDIN I HARISA, GAMAL; EL-HALAWANY, NERMIN; M GHONAIM, MABROUK (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-16)
    Oxidative stress may play a key role in the pathogenesis of diabetic nephropathy. Propolis and its extract have antioxidant properties. The effect of ethanolic extract of propolis against experimental diabetes mellitus-associated ...
  • EFFECT OF HYDROPHILIC NATURAL GUMS IN FORMULATION OF ORAL-CONTROLLED RELEASE MATRIX TABLETS OF PROPRANOLOL HYDROCHLORIDE 
    RAJESH, KS; VENKATARAJU, MP; GOWDA, DV (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-17)
    In order to develop a controlled delivery of highly water-soluble propranolol hydrochloride (PPHCl) using hydrophilic natural gums (xanthan gum [X] and locust bean gum [LBG]) as cost-effective, nontoxic, easily available. ...
  • QUALITY OF CEFTRIAXONE IN PAKISTAN: REALITY AND RESONANCE 
    ALI, OBAID (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-18)
    The quality of pharmaceuticals is a global concern, counterfeit/ poor quality/ substandard medicines can cause harms in various ways: In a number of developing countries including Pakistan there is reportedly a high incidence ...
  • FREQUENCY OF ASPIRIN RESISTANCE IN PATIENTS WITH CORONORY ARTERY DISEASE IN PAKISTAN 
    AKHTAR, NAVEED; JUNAID, AYESHA; KHALID, AYESHA; AHMED, WAQAS; ALI SHAH, MUMTAZ; UR RAHMAN, HABIB (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-19)
    Aspirin resistance is an emerging clinical entity. However the data available on aspirin resistance in Asian population is scarce. This study was initiated to prospectively evaluate the frequency of aspirin resistance ...
  • SOLID DISPERSIONS: A REVIEW 
    K, DHIRENDRA; S, LEWIS; N, UDUPA; K, ATIN (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-04-20)
    Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of hydrophobic drugs. This article reviews the various preparation techniques ...
  • ANTI-BACTERIAL ACTIVITY OF ETHANOLIC EXTRACT OF INDONEESIELLA ECHIOIDES (L) NEES. EVALUATED BY THE FILTER PAPER DISC METHOD 
    LATIEF QADRIE, ZULFKAR; JACOB, BEENA; ANANDAN, R; RAJKAPOOR, B; RAHAMATH ULLA, MOHAMMED (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-07-01)
    The study was carried out to investigate the antibacterial activity of the ethanolic extracts of Indoneesiella echioides (L) Nees. was evaluated by the filter paper disc method. This method is based on the diffusion of ...
  • TOXICITY OF TRIGONELLA FOENUM GRAECUM (FENUGREEK) IN BONE MARROW CELL PROLIFERATION IN RAT 
    ARAEE, M; NOROUZI, M; HABIBI, G; SHEIKHVATAN, M (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-07-02)
    Fenugreek has a wide range of medical applications and its medicinal use has been clear in several studies, however, few studies are available on effects on haematopoietic stem cell of bone marrow. The goal of the present ...
  • COMPARATIVE STUDY OF TWO BACTERIOCINS PRODUCED BY REPRESENTATIVE INDIGENOUS SOIL BACTERIA 
    SALEEM, FARAH; AHMAD, SAMIA; YAQOOB, ZOBIA; AJAZ RASOOL, SHEIKH (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-07-02)
    The aim of this research work was to identify and characterized the bacteriocins produced by soil-associated bacteria. Bacillocin from Bacillus brevis Bb and pyocin from Pseudomonas aeruginosa Pa were found bioactive only ...
  • DESIGN AND EVALUATION OF ITRACONAZOLE LOADED SOLID LIPID NANOPARTICULATE SYSTEM FOR IMPROVING THE ANTIFUNGAL THERAPY 
    MUKHERJEE, SWARUPANANDA; RAY, SUBHABRATA; THAKUR, RS (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-07-03)
    The objective of the study was to design and evaluate Itraconazole loaded solid lipid nanoparticles (SLNs) drug delivery system, where Itraconazole nanoparticles with suitable size ranges are expected to improve ...
  • DICLOFENAC INHIBITS PROLIFERATION BUT NOT NGF-INDUCED DIFFERENTIATION OF PC12 CELLS 
    RAJABALIAN, SAEED; SHAMSI MEIMANDI, MANZUMEH; BADINLOO, MARZIYEH (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2009-07-03)
    Diclofenac is a non-steroidal anti-inflammatory drug that is prescribed for treatment of rheumatic diseases and as an analgesic. Although the information about these side effects has been widely reported, little is know ...

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