Volume 23: Recent submissions

  • HPLC DETERMINATION OF IMATINIB IN PLASMA AND TISSUES AFTER MULTIPLE ORAL DOSE ADMINISTRATION TO MICE 
    M, TEOH; P, NARAYANAN; KS, MOO; S, RADHAKRISMAN; R, PILLAPPAN; NI, BUKHARI; I, SEGARRA (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2010-01-20)
    Imatinib inhibits Bcr-Abl, c-KIT and PDGFR kinases. It is approved for the treatment of chronic myeloid leukemia (CML), gastrointestinal stromal tumors (GIST) and has further therapeutic potential. Male ICR mice were given ...
  • ERYTHROCYTES AS CARRIER FOR PREDNISOLONE: IN VITRO AND IN VIVO EVALUATION 
    V SHAVI, GOPAL; C DOIJAD, RAJENDRA; B DESHPANDE, PRAFUL; FV, MANVI; REDDY MEKA, SREENIVASA; UDUPA, NAYANABHIRAMA; R, OMPRAKASH; K, DHIRENDRA (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2010-04-13)
    Resealed erythrocytes, as drug delivery system has tremendous potential to achieve site specificity and prolonged release of drug thereby enhancing therapeutic index and patient compliance. In the present investigation ...
  • EFFECT OF LITHIUM METAL ON THE CHEMICAL STATUS OF GLUTATHIONE (GSH) PRESENT IN WHOLE BLOOD (ESPECIALLY IN PLASMA AND CYTOSOLIC FRACTION IN HUMAN BLOOD) 
    KHAN, HAROON; UMER JAN, SYED; HASHMATULLAH, HASHMATULLAH; KHAN, M FARID; AHMAD KHAN, KAMRAN; UR REHMAN, ASIM; WAHAB, ABDUL (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2010-04-12)
    Lithium remains a mainstay in the acute and prophylactic treatment of bipolar affective disorder. It is used in the augmentation of antidepressant treatment and, less frequently, in the augmentation of antipsychotic treatment ...
  • PRELIMINARY PHARMACOLOGICAL STUDY OF THE PTEROCARPANS MACCKIAN AND TRIFOLIRHIZIN ISOLATED FROM THE ROOTS OF ONONIS VAGINALIS 
    S, MAGED; KADER, ABDEL (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2010-04-11)
    Preliminary pharmacological study was conducted for the pterocarpans macckian (Mac) and trifolirhizin (Trif). The two compounds isolated from Ononis vaginalis were tested for their hepatoprotective effects against ...
  • FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF THE ETORICOXIB. 
    MARGRET CHANDIRA, R; VENKATAESWARLU, BS; KUMUDHAVALLI, MV; BHOWMIK, DEBJIT; JAYAKAR, B (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2010-04-10)
    The demand for mouth dissolving tablets has been growing during the last decade especially for elderly and children who have swallowing difficulties. Etoricoxib is a new non-steroidal anti-inflammatory drug (NSAID) with ...
  • ANTIOXIDANT LEVEL IN NORMAL AND DIALYZED PATIENTS USING FRAP METHOD 
    MUSTAFA, GHULAM; ULLAH KHAN, IKRAM; KHALID KHAN, M.; SUALEH, MOHAMMAD (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2010-04-09)
    To examine the serum antioxidant levels like vit-C, vit-E and glutathione in patients with renal diseases who were subjected to dialysis and to evaluate the antioxidant by FRAP method. To find out the involvement of ...
  • THE INTRACEREBROVENTRICULAR (ICV) ADMINISTRATION OF W-7, A CALMODULIN INHIBITOR, ATTENUATES THE DEVELOPMENT OF MORPHINE TOLERANCE IN RATS 
    SEPEHRI, GHOLAMREZA; SHEIBANI, VAHID; AZARANG, AFROOZ; SHAMSIZADEH, ALI; REZA AFARINESH, MOHAMMAD; AZIZOLLAHI, SAEED; SEPEHRI, EHSAN (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2010-04-08)
    The present study was performed to determine the effect of intracerebroventricular (ICV) administration of W7, a specific calmodulin inhibitor, on the development of tolerance to antinociceptive effect morphine administration. ...
  • ANTIOXIDANT AND FREE RADICAL SCAVENGING ACTIVITY OF H. OFFICINALIS L. VAR. ANGUSTIFOLIUS, V. ODORATA, B. HYRCANA AND C. SPECIOSUM 
    ALI EBRAHIMZADEH, MOHAMMAD; NABAVI, SEYED MOHAMMAD; NABAVI, SEYED FAZEL; BAHRAMIAN, FATEMEH; BEKHRADNIA, AHMAD REZA (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2010-01-20)
    Extracts of 4 medicinal and aromatic plants were investigated for their antioxidant potency employing six various established in vitro system: H. officinalis L. var. angustifolius aerial parts, C. speciosum flowers, V. ...
  • SUBCHRONIC TOXICITY STUDIES OF THE ETHANOLIC ROOT EXTRACT OF CROTON ZAMBESICUS 
    OKOKON, JUDE E; NWAFOR, PAUL A; D EKPO, MEMFIN (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2010-04-07)
    Subchronic toxicity study of the crude root extract of Croton zambesicus (27-81mg/kg), which is used traditionally as malarial remedy, was carried out in rodents to evaluate the safety profile. Effect of the extract ...
  • MECHANICAL PROPERTIES AND WATER VAPOUR PERMEABILITY OF FILM FROM HARUAN (Channa striatus) AND FUSIDIC ACID SPRAY FOR WOUND DRESSING AND WOUND HEALING 
    FEBRIYENTI, FEBRIYENTI; MOHD. NOOR, AZMIN; BIN BAI, SARINGAT (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2010-04-07)
    Aerosol is a new dosage form for wound dressing and wound healing. Concentrate of aerosols which were prepared for wound dressing and wound healing will produced films after sprayed onto the surface of wounds. The aim ...
  • GREEN TEA AMELIORATES RENAL OXIDATIVE DAMAGE INDUCED BY GENTAMICIN IN RATS 
    ABDEL-RAHEEM, IHAB T; A EL-SHERBINY, GAMAL; TAYE, ASHRAF (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2010-01-20)
    Recent studies indicate that free radicals are important mediators of renal damage induced by gentamicin (GM), an aminoglycoside antibiotic widely used in treating severe gram-negative infections. Green tea extract ...
  • DEVELOPMENT OF NEW OPHTHALMIC SUSPENSION PREDNISOLONE ACETATE 1% 
    AKRAM, MUHAMMAD; BAQIR SHYUM NAQVI, SYED; GAUHAR, SHAHNAZ (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2010-04-05)
    Formulation of a new Prednisolone acetate (1%) ophthalmic suspension to obtain a better contactibility of the drug at the site of action. The formulation was evaluated and optimized based on physiological, physicochemical ...
  • COMPARATIVE EVALUATION OF DIFFERENT EXTRACTS OF LEAVES OF PSIDIUM GUAJAVA LINN. FOR HEPATOPROTECTIVE ACTIVITY 
    K ROY, CHANCHAL; KUMAR DAS, AMIT (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2010-01-20)
    The study was designed to evaluate the hepatoprotective activity of different extracts (petroleum ether, chloroform, ethyl acetate, methanol and aqueous) of P. guajava in acute experimental liver injury induced by carbon ...
  • INTERACTION STUDY BETWEEN LEVOFLOXACIN AND OMEPRAZOLE USING URINARY PHARMACOKINETIC DATA 
    FARHANA FARUQUEE, CHOWDHURY; ULLAH, MD. ASHIK; ABUL KALAM AZAD, MOHAMMAD; RAYHAN, MD. ISRAT; PARVEEN, SEHELI; HASNAT, ABUL (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2010-04-04)
    The objective of this study was to observe the drug interaction between levofloxacin and omeprazole using urinary excretion data. Levofloxacin tablet and omeprazole capsule were administered separately as well as ...
  • IMPACT OF THE AQUEOUS EXTRACT OF ECLIPTA ALBA ON MATERNAL AGGRESSION IN RATS 
    BANJ, DAVID; JF BANJI, OTILIA; ANNAMALAI, AR; M, SHANTHMURTHY (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2010-04-03)
    Parturient females display impulsive behavior represented in the form of aggressive bouts when exposed to conspecifics. Prolonged aggression during the postpartum period could affect maternal care. Eclipta alba is traditionally ...
  • TOXIC EFFECTS OF MULTIPLE ANTICANCER DRUGS ON SKIN 
    KAMIL, NOOR; KAMIL, SABA; P. AHMED, SHAHIDA; ASHRAF, RIZWAN; KHURRAM, MOHAMMAD; OBAID ALI, MUHAMMAD (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2010-01-20)
    In this study, cutaneous toxicities associated with the administration of chemotherapy in combination are discussed. Rapidly growing cells are the targets of chemotherapy, so the skin, hair follicles, and nail matrix are ...
  • THYMOQUINONE SUPPLEMENTATION AMELIORATES ACUTE ENDOTOXEMIA-INDUCED LIVER DYSFUNCTION IN RATS 
    HELAL, GOUDA K (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2010-04-02)
    Endotoxemia caused by lipopolysaccharide (LPS) produced an inflammatory condition contributing to multiple organ failure. This study was carried out to investigate the effects of thymoquinone (TQ), the main constituent of ...
  • SYSTEMATIC REVIEW ON “VITAMIN E AND PREVENTION OF COLORECTAL CANCER” 
    ARAIN, MUBASHIR ASLAM; QADEER, ASMA ABDUL (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2010-04-01)
    Colorectal cancers (CRC) are highly prevalent cancer all over the world and need appropriate and timely prevention and treatment. Since years it has been argued that antioxidant vitamins have a potential role in the prevention ...
  • SELECTION OF STREPTOMYCES ISOLATES FROM TURKISH KARSTIC CAVES AGAINST ANTIBIOTIC RESISTANT MICROORGANISMS 
    YÜCEL, SEMRA; YAMAÇ, MUSTAFA (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2010-01-20)
    In this work, actinomycetes isolates were isolated from rock wall and speleothem surfaces and soil samples of 19 karstic caves in Turkey. Out of 290 isolates isolated, 180 isolates (62%) exhibited antimicrobial activity ...

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