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Browsing Issue 01 by Issue Date

Browsing Issue 01 by Issue Date

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  • HPLC DETERMINATION OF IMATINIB IN PLASMA AND TISSUES AFTER MULTIPLE ORAL DOSE ADMINISTRATION TO MICE 
    M, TEOH; P, NARAYANAN; KS, MOO; S, RADHAKRISMAN; R, PILLAPPAN; NI, BUKHARI; I, SEGARRA (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2010-01-20)
    Imatinib inhibits Bcr-Abl, c-KIT and PDGFR kinases. It is approved for the treatment of chronic myeloid leukemia (CML), gastrointestinal stromal tumors (GIST) and has further therapeutic potential. Male ICR mice were given ...
  • THE EFFECTS OF SOME PERMEABILITY ENHANCERS ON THE PERCUTANEOUS ABSORPTION OF LIDOCAINE 
    MOHAMMADI-SAMANI, SOLIMAN; JAMSHIDZADEH, AKRAM; MONTASERI, HASHEM; RANGBAR-ZAHEDANI, MOJGAN (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2010-01-20)
    Local anesthesia of the intact skin is difficult because of the barrier properties of skin to epicutaneous penetration of local anesthetic drugs. Using local anesthetics with combination of penetration enhancers could ...
  • COMPARATIVE EVALUATION OF DIFFERENT EXTRACTS OF LEAVES OF PSIDIUM GUAJAVA LINN. FOR HEPATOPROTECTIVE ACTIVITY 
    K ROY, CHANCHAL; KUMAR DAS, AMIT (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2010-01-20)
    The study was designed to evaluate the hepatoprotective activity of different extracts (petroleum ether, chloroform, ethyl acetate, methanol and aqueous) of P. guajava in acute experimental liver injury induced by carbon ...
  • IN VITRO ANTIMICROBIAL ACTIVITY OF FOUR FICUS CARICA LATEX FRACTIONS AGAINST RESISTANT HUMAN PATHOGENS (ANTIMICROBIAL ACTIVITY OF FICUS CARICA LATEX) 
    AREF, HOUDA LAZREG; HADJ SALAH, KARIMA BEL; CHAUMONT, JEAN PIERRE; FEKIH, ABDELWAHEB; AOUNI, MAHJOUB; SAID, KHALED (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2010-01-20)
    Methanolic, hexanoïc, chloroformic and ethyl acetate extracts of Ficus carica latex were investigated for their in vitro antimicrobial proprieties against five bacteria species and seven strains of fungi. The green fruit ...
  • BONE MINERAL DENSITY AND VITAMIN D RECEPTOR POLYMORPHISM IN β-THALASSEMIA MAJOR 
    H EL-EDEL, RAWHIA; GHONAIM, MABROUK M; M ABO-SALEM, OSAMA; M EL-NEMR, FATHIA (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2010-01-20)
    Osteoporosis is the most prevalent bone complication in β-thalassemic patients despite regular transfusions and iron chelation therapy. Although its etiology is multi-factorial, genetic factors play an important role in ...
  • SEASONAL VARIATION OF TOTAL PHENOLIC, ANTIOXIDANT ACTIVITY AND MINERALS IN FRESH TEA SHOOTS (CAMELLIA SINENSIS VAR. SINENSIS) 
    ERTURK, YASAR; ERCISLI, SEZAI; SENGUL, MEMNUNE; ESER, ZEYNEP; HAZNEDAR, AYHAN; TURAN, METIN (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2010-01-20)
    Seasonal variation of total phenolics, antioxidant activity and minerals in fresh tea shoots, consisting of one apical bud and two adjoining leaves sampled from Muradiye, Tuglali, Gundogdu, Enstitu 9, Hamzabey, Hayrat and ...
  • GREEN TEA AMELIORATES RENAL OXIDATIVE DAMAGE INDUCED BY GENTAMICIN IN RATS 
    ABDEL-RAHEEM, IHAB T; A EL-SHERBINY, GAMAL; TAYE, ASHRAF (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2010-01-20)
    Recent studies indicate that free radicals are important mediators of renal damage induced by gentamicin (GM), an aminoglycoside antibiotic widely used in treating severe gram-negative infections. Green tea extract ...
  • IMMUNOMODULATORY EFFECTS OF ZERUMBONE ISOLATED FROM ROOTS OF ZINGIBER ZERUMBET 
    KEONG, YEAP SWEE; BANU ALITHEEN, NOORJAHAN; MUSTAFA, SHUHAIMI; ABDUL AZIZ, SURAINI; ABDUL RAHMAN, MASHITOH; MANAF ALI, ABDUL (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2010-01-20)
    In this study, the immunomodulatory effects of zerumbone isolated from Zingiber zerumbet were investigated by evaluating the effects of this compound towards the lymphocytes proliferation (mice thymocytes, mice splenocytes ...
  • ANTIOXIDANT AND FREE RADICAL SCAVENGING ACTIVITY OF H. OFFICINALIS L. VAR. ANGUSTIFOLIUS, V. ODORATA, B. HYRCANA AND C. SPECIOSUM 
    ALI EBRAHIMZADEH, MOHAMMAD; NABAVI, SEYED MOHAMMAD; NABAVI, SEYED FAZEL; BAHRAMIAN, FATEMEH; BEKHRADNIA, AHMAD REZA (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2010-01-20)
    Extracts of 4 medicinal and aromatic plants were investigated for their antioxidant potency employing six various established in vitro system: H. officinalis L. var. angustifolius aerial parts, C. speciosum flowers, V. ...
  • TOXIC EFFECTS OF MULTIPLE ANTICANCER DRUGS ON SKIN 
    KAMIL, NOOR; KAMIL, SABA; P. AHMED, SHAHIDA; ASHRAF, RIZWAN; KHURRAM, MOHAMMAD; OBAID ALI, MUHAMMAD (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2010-01-20)
    In this study, cutaneous toxicities associated with the administration of chemotherapy in combination are discussed. Rapidly growing cells are the targets of chemotherapy, so the skin, hair follicles, and nail matrix are ...
  • IMMUNOGLOBULIN LEVELS OF VITILIGO PATIENTS 
    ALI, RUBAIYA; SHAMSUL AHSAN, MOHAMMAD; KALAM AZAD, ABUL; ASHIK ULLAH, MD.; BARI, WASIMUL; NAZRUL ISLAM, SHEIKH; YEASMIN, SABINA; HASNAT, ABUL (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2010-01-20)
    In the present study, the serum immunoglobulin profiles of vitiligo patients were compared with that of cohort control and evaluated the correlation between immunoglobulin level with their socioeconomic factors and nutritional ...
  • STUDIES ON THE CHEMICAL COMPOSITION OF KOHL STONE BY X-RAY DIFFRACTOMETER 
    ULLAH, PERVAIZ HABIB; MAHMOOD, ZAFAR ALAM; SUALEH, MOHAMMAD; ZOHA, SMS (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2010-01-20)
    Use of Kohl (Surma) creates toxicity or protects eye, is one of the most controversial topic of modern medicines. However, modern researches show that kohl forms a thin film on the eye lens thus avoiding the direct contract ...
  • ANTIBACTERIAL EFFECT OF NSAIDS ON CLINICAL ISOLATES OF URINARY TRACT INFECTION AND DIABETIC FOOT INFECTION 
    AKHTER, TASNEEM; BAQAI, RAKHSHANDA; AZIZ, MUBASHAR (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2010-01-20)
    Non Steroidal Anti-inflammatory Drugs (NSAIDS) are a group of chemically dissimilar agents that have primary effect of inhibition of prostaglandin’s synthesis. Aspirin (Acetyl Salicylic Acid) is used as an analgesic, anti ...
  • SELECTION OF STREPTOMYCES ISOLATES FROM TURKISH KARSTIC CAVES AGAINST ANTIBIOTIC RESISTANT MICROORGANISMS 
    YÜCEL, SEMRA; YAMAÇ, MUSTAFA (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2010-01-20)
    In this work, actinomycetes isolates were isolated from rock wall and speleothem surfaces and soil samples of 19 karstic caves in Turkey. Out of 290 isolates isolated, 180 isolates (62%) exhibited antimicrobial activity ...
  • PHARMACODYNAMIC INTERACTION OF GARLIC WITH PROPRANOLOL IN ISCHEMIA-REPERFUSION INDUCED MYOCARDIAL DAMAGE 
    MOHAMMED, SYED; ASDAQ, BASHEERUDDIN; INAMDAR, MOHAMMED NASEERUDDIN; ASAD, MOHAMMED (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2010-01-20)
    The present study was undertaken to explore the interaction of garlic homogenate (GH) with propranolol (PRO) on ischemia-reperfusion injury (IRI) in isolated rat heart preparation. Albino rats were treated with GH at three ...
  • ANTIMICROBIAL ACTIVITY OF ROOT EXTRACT AND CRUDE FRACTIONS OF CROTON ZAMBESICUS 
    OKOKON, JUDE E; A NWAFOR, PAUL (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2010-01-20)
    The root extract and fractions of Croton zambesicus were screened for antimicrobial activity against some typed and pure cultures of bacterial and fungal species. These were carried out by the Plate -hole diffusion method ...
  • PRONIOSOMES AS DRUG CARRIERS 
    SANKAR, V; RUCKMANI, K; DURGA, S; JAILANI, S (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2010-01-20)
    Approaches to stabilize niosomal drug delivery system without affecting its properties of merits have resulted in the development of the promising drug carrier, proniosomes. Proniosomes is dry formulation using suitable ...
  • IMMUNOMODULATORY ACTIVITY OF METHANOLIC EXTRACT OF MORUS ALBA LINN. (MULBERRY) LEAVES 
    ESWARA, SHENDIGE; BHARANI, RAO; ASAD, MOHAMMED; SAMSON DHAMANIGI, SUNIL; CHANDRAKALA, GOWDA KALLENAHALLI (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2010-01-20)
    The leaves of Morus alba Linn. (Family: Moraceae) commonly known as mulberry are mainly used as food for the silkworms and they are sometimes eaten as vegetable or used as cattle fodder in different parts of the world. The ...
  • HERBAL TREATMENT FOR CARDIOVASCULAR DISEASE THE EVIDENCE BASED THERAPY 
    ALAM MAHMOOD, ZAFAR; SUALEH, MOHAMMAD; ZAFAR MAHMOOD, SAAD BIN; AHMED KARIM, MAHWISH (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2010-01-20)
    ABSTRACT More than 2000 plants have been listed in the Traditional (Herbal/Alternative) systems of medicine and some of these are providing comprehensive relief to the people suffering from cardio-vascular diseases, specially ...
  • ANTIOXIDANT ACTIVITY OF AERIAL PARTS OF TRIBULUS ALATUS IN RATS 
    KADRY, H.; ABOU BASHA, L.; GINDI, O. EL; TEMRAZ, A. (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2010-01-20)
    The antioxidant activity of alcoholic extract of Tribulus alatus was investigated by determination of blood glutathione, serum ascorbic acid and serum superoxide dismutase in rats. All groups treated with aerial parts ...

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