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TOXICITY OF TRIGONELLA FOENUM GRAECUM (FENUGREEK) IN BONE MARROW CELL PROLIFERATION IN RAT

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dc.contributor.author ARAEE, M
dc.contributor.author NOROUZI, M
dc.contributor.author HABIBI, G
dc.contributor.author SHEIKHVATAN, M
dc.date.accessioned 2022-11-28T09:26:43Z
dc.date.available 2022-11-28T09:26:43Z
dc.date.issued 2009-07-02
dc.identifier.citation Araee, M., Norouzi, M., Habibi, G., & Sheikhvatan, M. (2009). Toxicity of Trigonella foenum graecum (Fenugreek) in bone marrow cell proliferation in rat. Pakistan Journal of Pharmaceutical Sciences, 22(2). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14120
dc.description.abstract Fenugreek has a wide range of medical applications and its medicinal use has been clear in several studies, however, few studies are available on effects on haematopoietic stem cell of bone marrow. The goal of the present study was to investigate the effect of Fenugreek on fetal macroscopic diameters and microscopic bone marrow cell histological changes in its teratogenic dosages. Fenugreek decoction was dissolved in 1.5 milliliter distilled water and injected intraperitoneumly in three dosages of 0.8 g/kg, 1.6 g/kg, and 3.2 g/kg for three groups of Wistar female rats mated by Wistar male. For another group (as control group) only 1.5 milliliter distilled water was injected. Bone marrow tissue was prepared from rat fetus and was cut using a microtome and stained with hematoxylin and eosin. Sections were evaluated for changes using light microscope. LD50 for the measurement of teratogenic dosage of fenugreek was 4.1 and 3.5 g/kg in female and male rat, respectively. There was a positive relation between the injected drug dosage and fetal mortality rate. Among all fetal diameters, ear to ear diameter was decreased in groups received Fenugreek decoction. The severity of stem cell histological changes caused by 3.2 g/kg drug injection was lower than distilled water injection and in evaluation of other cells, differences in the severity of histological changes across three groups with different drug dosages and control group was detected. Fenugreek in teratogenic dosages can decrease the severity of bone marrow cell proliferation and increase fetal mortality rate. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Fenugreek en_US
dc.subject bone marrow en_US
dc.subject fetal mortality en_US
dc.subject herbal medicine en_US
dc.title TOXICITY OF TRIGONELLA FOENUM GRAECUM (FENUGREEK) IN BONE MARROW CELL PROLIFERATION IN RAT en_US
dc.type Article en_US


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