Abstract:
The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solutions due to rapid
pre-corneal elimination of the drug may be overcome by the use of in situ gel forming systems that are instilled
as drops into the eye and then undergo a sol-gel transition in the cul-de-sac. The present work describes the
formulation and evaluation of an ophthalmic delivery system of an antibacterial agent ofloxacin, based on the
concept of ion-activated in situ gelation. Sodium alginate was used as the gelling agent in combination with
HPC (Hydroxy Propyl Cellulose) that acted as a viscosity-enhancing agent. In vitro release studies indicated
that the alginate/HPC solution retained the drug better than the alginate or HPC solutions alone. The
formulations were therapeutically efficacious, sterile, stable and provided sustained release of the drug over a
period of time. These results demonstrate that the developed system is an alternative to conventional
ophthalmic drops, patient compliance, industrially oriented and economical.
