dc.contributor.author |
ABRAHAM, SINDHU |
|
dc.contributor.author |
FURTADO, SHARON |
|
dc.contributor.author |
S, BHARATH |
|
dc.contributor.author |
BV, BASAVARAJ |
|
dc.contributor.author |
R, DEVESWARAN |
|
dc.contributor.author |
V, MADHAVAN |
|
dc.date.accessioned |
2022-11-28T09:55:10Z |
|
dc.date.available |
2022-11-28T09:55:10Z |
|
dc.date.issued |
2009-04-10 |
|
dc.identifier.citation |
Abraham, S., Furtado, S., Bharath, S., Basavaraj, B. V., Deveswaran, R., & Madhavan, V. (2009). Sustained ophthalmic delivery of ofloxacin from an ion-activated in situ gelling system. Pakistan journal of pharmaceutical sciences, 22(2). |
en_US |
dc.identifier.issn |
1011-601X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/14128 |
|
dc.description.abstract |
The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solutions due to rapid
pre-corneal elimination of the drug may be overcome by the use of in situ gel forming systems that are instilled
as drops into the eye and then undergo a sol-gel transition in the cul-de-sac. The present work describes the
formulation and evaluation of an ophthalmic delivery system of an antibacterial agent ofloxacin, based on the
concept of ion-activated in situ gelation. Sodium alginate was used as the gelling agent in combination with
HPC (Hydroxy Propyl Cellulose) that acted as a viscosity-enhancing agent. In vitro release studies indicated
that the alginate/HPC solution retained the drug better than the alginate or HPC solutions alone. The
formulations were therapeutically efficacious, sterile, stable and provided sustained release of the drug over a
period of time. These results demonstrate that the developed system is an alternative to conventional
ophthalmic drops, patient compliance, industrially oriented and economical. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi |
en_US |
dc.subject |
Ophthalmic delivery systems |
en_US |
dc.subject |
sodium alginate |
en_US |
dc.subject |
in situ gelling |
en_US |
dc.subject |
ofloxacin |
en_US |
dc.subject |
sustained |
en_US |
dc.title |
SUSTAINED OPHTHALMIC DELIVERY OF OFLOXACIN FROM AN ION-ACTIVATED IN SITU GELLING SYSTEM |
en_US |
dc.type |
Article |
en_US |