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SUSTAINED OPHTHALMIC DELIVERY OF OFLOXACIN FROM AN ION-ACTIVATED IN SITU GELLING SYSTEM

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dc.contributor.author ABRAHAM, SINDHU
dc.contributor.author FURTADO, SHARON
dc.contributor.author S, BHARATH
dc.contributor.author BV, BASAVARAJ
dc.contributor.author R, DEVESWARAN
dc.contributor.author V, MADHAVAN
dc.date.accessioned 2022-11-28T09:55:10Z
dc.date.available 2022-11-28T09:55:10Z
dc.date.issued 2009-04-10
dc.identifier.citation Abraham, S., Furtado, S., Bharath, S., Basavaraj, B. V., Deveswaran, R., & Madhavan, V. (2009). Sustained ophthalmic delivery of ofloxacin from an ion-activated in situ gelling system. Pakistan journal of pharmaceutical sciences, 22(2). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14128
dc.description.abstract The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solutions due to rapid pre-corneal elimination of the drug may be overcome by the use of in situ gel forming systems that are instilled as drops into the eye and then undergo a sol-gel transition in the cul-de-sac. The present work describes the formulation and evaluation of an ophthalmic delivery system of an antibacterial agent ofloxacin, based on the concept of ion-activated in situ gelation. Sodium alginate was used as the gelling agent in combination with HPC (Hydroxy Propyl Cellulose) that acted as a viscosity-enhancing agent. In vitro release studies indicated that the alginate/HPC solution retained the drug better than the alginate or HPC solutions alone. The formulations were therapeutically efficacious, sterile, stable and provided sustained release of the drug over a period of time. These results demonstrate that the developed system is an alternative to conventional ophthalmic drops, patient compliance, industrially oriented and economical. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Ophthalmic delivery systems en_US
dc.subject sodium alginate en_US
dc.subject in situ gelling en_US
dc.subject ofloxacin en_US
dc.subject sustained en_US
dc.title SUSTAINED OPHTHALMIC DELIVERY OF OFLOXACIN FROM AN ION-ACTIVATED IN SITU GELLING SYSTEM en_US
dc.type Article en_US


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