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BIOEQUIVALENCE STUDIES OF TWO BRANDS OF MELOXICAM TABLETS IN HEALTHY PAKISTANI VOLUNTEERS

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dc.contributor.author FARID HASAN, SYED MUHAMMAD
dc.contributor.author HARRIS SHOAIB, MUHAMMAD
dc.contributor.author HASSAN, FOUZIA
dc.contributor.author REHMAN, INAM-UR
dc.date.accessioned 2022-11-28T10:11:10Z
dc.date.available 2022-11-28T10:11:10Z
dc.date.issued 2009-04-15
dc.identifier.citation Hasan, S. M., Shoaib, M. H., Hassan, F., & Rehman, I. U. (2009). Bioequivalence studies of two brands of meloxicam tablets in healthy Pakistani volunteers. Pak J Pharm Sci, 22(2), 199-204. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14133
dc.description.abstract The pharmacokinetic parameters of two oral formulations of meloxicam tablets were compared in a randomized, single oral dose; two treatments cross over design in 12 healthy male volunteers belonging to Pakistan under fasting conditions. After an overnight fast, the volunteers received 30 mg meloxicam and the blood samples were collected up to 96 hours and drug concentrations were determined by a validated HPLC method. Various pharmacokinetic parameters were determined from the plasma concentration-time curves of both formulations. The 90% confidence intervals obtained by analysis of variance were 87-94% for Cmax and 88-97% for AUC0-t, that fell well within the acceptance range of 80-125%. Also, no significant difference (α=0.05, Wilcoxon Signed rank test) were detected between Tmax of both formulations. The two formulations were well tolerated and no adverse effect was reported during the study. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Bioequivalence en_US
dc.subject meloxicam tablets en_US
dc.subject anti-inflammatory en_US
dc.subject analgesic en_US
dc.subject antipyretic drugs en_US
dc.title BIOEQUIVALENCE STUDIES OF TWO BRANDS OF MELOXICAM TABLETS IN HEALTHY PAKISTANI VOLUNTEERS en_US
dc.type Article en_US


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