Abstract:
In order to develop a controlled delivery of highly water-soluble propranolol hydrochloride (PPHCl) using
hydrophilic natural gums (xanthan gum [X] and locust bean gum [LBG]) as cost-effective, nontoxic, easily
available. The granules of PPHCl were prepared by wet granulation method using a different ratios drug: gum
ratios of X, LBG and XLBG(X and LBG in 1:1 ratios). To increase the flowability and compressibility of the
granules, and to prevent its adhesion to punch and die, magnesium stearate and talc were added to the granules
in 1:2 ratios before punching. The tablets was analysed to determine hardness, friability, % assay and invitro
release study was carried out.
The release of PPHCl from a gelatinous swollen mass, which controls the diffusion of drug molecules through
the polymeric material into aqueous medium. The XLBG matrices shows precise controlled release than the X
and LBG matrices because of burst effect and fast release in case of X and LBG matrices respectively and there
was no chemical interaction between drug and polymers in XLBG formulation as confirmed by FTIR studies.
First pass effect of PPHCl can be avoided by these formulations. Matrices with XLBG show zero-order release
via swelling, diffusion and relaxation mechanism.
The XLBG matrices leads to more precise result than X and LBG alone by the utilization of synergistic
interaction between two biopolymers and uniformity in the hydration layer in dissolution media. However,
according to the similarity factor (f2) XLBG3 were the most similar formulation to Lol-SR as the reference
standard.
