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EFFECT OF HYDROPHILIC NATURAL GUMS IN FORMULATION OF ORAL-CONTROLLED RELEASE MATRIX TABLETS OF PROPRANOLOL HYDROCHLORIDE

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dc.contributor.author RAJESH, KS
dc.contributor.author VENKATARAJU, MP
dc.contributor.author GOWDA, DV
dc.date.accessioned 2022-11-28T10:19:00Z
dc.date.available 2022-11-28T10:19:00Z
dc.date.issued 2009-04-17
dc.identifier.citation Rajesh, K. S., Venkataraju, M. P., & Gowda, D. V. (2009). Effect of hydrophilic natural gums in formulation of oral-controlled release matrix tablets of propranolol hydrochloride. Pakistan Journal of Pharmaceutical Sciences, 22(2). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14135
dc.description.abstract In order to develop a controlled delivery of highly water-soluble propranolol hydrochloride (PPHCl) using hydrophilic natural gums (xanthan gum [X] and locust bean gum [LBG]) as cost-effective, nontoxic, easily available. The granules of PPHCl were prepared by wet granulation method using a different ratios drug: gum ratios of X, LBG and XLBG(X and LBG in 1:1 ratios). To increase the flowability and compressibility of the granules, and to prevent its adhesion to punch and die, magnesium stearate and talc were added to the granules in 1:2 ratios before punching. The tablets was analysed to determine hardness, friability, % assay and invitro release study was carried out. The release of PPHCl from a gelatinous swollen mass, which controls the diffusion of drug molecules through the polymeric material into aqueous medium. The XLBG matrices shows precise controlled release than the X and LBG matrices because of burst effect and fast release in case of X and LBG matrices respectively and there was no chemical interaction between drug and polymers in XLBG formulation as confirmed by FTIR studies. First pass effect of PPHCl can be avoided by these formulations. Matrices with XLBG show zero-order release via swelling, diffusion and relaxation mechanism. The XLBG matrices leads to more precise result than X and LBG alone by the utilization of synergistic interaction between two biopolymers and uniformity in the hydration layer in dissolution media. However, according to the similarity factor (f2) XLBG3 were the most similar formulation to Lol-SR as the reference standard. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Locust bean gum en_US
dc.subject xanthan gum en_US
dc.subject propranolol hydrochloride en_US
dc.subject controlled release en_US
dc.title EFFECT OF HYDROPHILIC NATURAL GUMS IN FORMULATION OF ORAL-CONTROLLED RELEASE MATRIX TABLETS OF PROPRANOLOL HYDROCHLORIDE en_US
dc.type Article en_US


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