Abstract:
Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of hydrophobic drugs. This article reviews the various preparation
techniques for solid dispersion and compiles some of the recent technology transfers. The different types of
solid dispersions based on the molecular arrangement have been highlighted. Some of the practical aspects to
be considered for the preparation of solid dispersions, such as selection of carrier and methods of
physicochemical characterization, along with an insight into the molecular arrangement of drugs in solid
dispersions are also discussed. Finally, an in-depth rationale for limited commercialization of solid dispersions
and recent revival has been considered.
